Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases

Basit Öğe Kaydı
dc.contributor.authorErtan, Yesim
dc.contributor.authorSezak, Murat
dc.contributor.authorTurhan, Tuncer
dc.contributor.authorKantar, Mehmet
dc.contributor.authorErsahin, Yusuf
dc.contributor.authorMutluer, Saffet
dc.contributor.authorVergin, Canan
dc.contributor.authorOniz, Haldun
dc.contributor.authorAkalin, Taner
dc.date.accessioned2019-10-27T20:51:23Z
dc.date.available2019-10-27T20:51:23Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractAtypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive infantile neoplasm of uncertain origin. This study was performed to assess the clinicopathologic and immunohistochemical features of four AT/RT cases. Two cases were male and two were female, and their ages ranged from 8 to 103 months. Tumors were located in the cerebellum (two cases), frontoparietal lobe (one case), and third ventricle (one case). Histopathologically, the tumors were composed of rhabdoid cells and undifferentiated small cells mixed with epithelial or mesenchymal components. However, one of the tumors was composed predominantly of a mesenchymal component mimicking a sarcoma. Immunohistochemically, vimentin (4/4), epithelial membrane antigen (4/4), cytokeratin (3/4), smooth muscle actin (4/4), glial fibrillary acidic protein (4/4), S-100 (4/4), and synaptophysin (1/4) were positive in varying proportions, while desmin and INI-1 were negative in all the cases. All of the patients died within a mean of 14 months due to tumor progression despite the chemotherapy. Only one of our patients lived for 40 months after the diagnosis. In conclusion, AT/RTs are aggressive tumors. They can occur in a variety of locations, such as the third ventricle. Morphologically, a large spectrum can be seen, like predominantly sarcoma in appearance, but immunohistochemistry is helpful in the correct diagnosis.en_US
dc.identifier.doi10.1007/s00381-009-0811-0en_US
dc.identifier.endpage711en_US
dc.identifier.issn0256-7040
dc.identifier.issue6en_US
dc.identifier.pmid19212771en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage707en_US
dc.identifier.urihttps://doi.org/10.1007/s00381-009-0811-0
dc.identifier.urihttps://hdl.handle.net/11454/43108
dc.identifier.volume25en_US
dc.identifier.wosWOS:000265683900014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofChilds Nervous Systemen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtypical teratoid/rhabdoid tumoren_US
dc.subjectINI-1en_US
dc.subjectPediatric brain tumoren_US
dc.titleAtypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four casesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu