The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants

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dc.contributor.authorTekgul, H
dc.contributor.authorGauvreau, K
dc.contributor.authorSoul, J
dc.contributor.authorMurphy, L
dc.contributor.authorRobertson, R
dc.contributor.authorStewart, J
dc.contributor.authorVolpe, J
dc.contributor.authorBourgeois, B
dc.contributor.authordu Plessis, AJ
dc.date.accessioned2019-10-27T19:19:15Z
dc.date.available2019-10-27T19:19:15Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVES. The objectives of this study were to delineate the etiologic profile and neurodevelopmental outcome of neonatal seizures in the current era of neonatal intensive care and to identify predictors of neurodevelopmental outcome in survivors. METHODS. Eighty-nine term infants with clinical neonatal seizures underwent neurologic examination, electroencephalography (EEG), neuroimaging, and extensive diagnostic tests in the newborn period. After discharge, all infants underwent regular neurologic evaluations and, at 12 to 18 months, formal neurodevelopmental testing. We tested the prognostic value of seizure etiology, neurologic examination, EEG, and neuroimaging. RESULTS. Etiology was found in 77 infants. Global cerebral hypoxia-ischemia, focal cerebral hypoxia-ischemia, and intracranial hemorrhage were most common. Neonatal mortality was 7%; 28% of the survivors had poor long-term outcome. Association between seizure etiology and outcome was strong, with cerebral dysgenesis and global hypoxia-ischemia associated with poor outcome. Normal neonatal period/early infancy neurologic examination was associated with uniformly favorable outcome at 12 to 18 months; abnormal examination lacked specificity. Normal/mildly abnormal neonatal EEG had favorable outcome, particularly if neonatal neuroimaging was normal. Moderate/ severely abnormal EEG, and multifocal/ diffuse cortical or primarily deep gray matter lesions, had a worse outcome. CONCLUSIONS. Mortality associated with neonatal seizures has declined although long-term neurodevelopmental morbidity remains unchanged. Seizure etiology and background EEG patterns remain powerful prognostic factors. Diagnostic advances have changed the etiologic distribution for neonatal seizures and improved accuracy of outcome prediction. Global cerebral hypoxia-ischemia, the most common etiology, is responsible for the large majority of infants with poor long-term outcome.en_US
dc.identifier.doi10.1542/peds.2005-1178en_US
dc.identifier.endpage1280en_US
dc.identifier.issn0031-4005
dc.identifier.issn1098-4275
dc.identifier.issue4en_US
dc.identifier.pmid16585324en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1270en_US
dc.identifier.urihttps://doi.org/10.1542/peds.2005-1178
dc.identifier.urihttps://hdl.handle.net/11454/38715
dc.identifier.volume117en_US
dc.identifier.wosWOS:000236540500060en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Acad Pediatricsen_US
dc.relation.ispartofPediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneonatal seizuresen_US
dc.subjectoutcomeen_US
dc.subjectdevelopmental delayen_US
dc.subjectcerebral palsyen_US
dc.subjectpostneonatal seizuresen_US
dc.titleThe current etiologic profile and neurodevelopmental outcome of seizures in term newborn infantsen_US
dc.typeArticleen_US

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