Prediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathy

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dc.contributor.authorPolat, Muzaffer
dc.contributor.authorSimsek, Ayse
dc.contributor.authorTansug, Nermin
dc.contributor.authorSezer, Rabia G.
dc.contributor.authorOzkol, Mine
dc.contributor.authorBaspinar, Pinar
dc.contributor.authorTekgul, Hasan
dc.date.accessioned2019-10-27T21:52:18Z
dc.date.available2019-10-27T21:52:18Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Hypoxic ischemic encephalopathy may result in many neurological deficits. It is crucial to make early diagnosis and assess the prognosis correctly. Aims: We aimed to determine the factors to evaluate the prognosis of hypoxic ischemic encephalopathy. Methods: Electroencephalography, neuroimaging, periodic neurological exams and a developmental test at 44-48 months after discharge from the hospital were performed on twenty five term newborn infants with clinical evidence of hypoxic ischemic encephalopathy. Results: Normal/mildly abnormal neonatal electroencephalography correlated with favorable outcome, particularly if neuroimaging was normal. The cranial MRI sensitivity was 83.3%, while the specificity was 57.9%, the positive predictive value was 38.5%, and the negative predictive value was 91.6%. Moderate/severely abnormal electroencephalography and multifocaVdiffuse cortical or deep gray matter lesions correlated with poor outcome. Conclusions: Newborn infants with hypoxic ischemic encephalopathy should be treated in neonatal intensive care units, assessed with periodic neurological examination, electroencephalogram and brain imaging. This would help to initiate early intervention and improve the outcome of patients. (C) 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejpn.2012.11.004en_US
dc.identifier.endpage293en_US
dc.identifier.issn1090-3798
dc.identifier.issue3en_US
dc.identifier.pmid23231917en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage288en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejpn.2012.11.004
dc.identifier.urihttps://hdl.handle.net/11454/47581
dc.identifier.volume17en_US
dc.identifier.wosWOS:000317870500012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofEuropean Journal of Paediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectroencephalographyen_US
dc.subjectHypoxic ischemic encephalopathyen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectNeurodevelopmental outcomeen_US
dc.titlePrediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathyen_US
dc.typeArticleen_US

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