Hemophagocytic Lymphohistiocytosis in Adults: Low Incidence of Primary Neoplasm as a Trigger in a Case Series from Turkey

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dc.contributor.authorArslan, Ferhat
dc.contributor.authorAlp, Sehnaz
dc.contributor.authorBuyukasik, Yahya
dc.contributor.authorOzkan, Melda Comert
dc.contributor.authorSahin, Fahri
dc.contributor.authorBasaran, Seniha
dc.contributor.authorCagatay, Arif Atahan
dc.contributor.authorEraksoy, Omer Haluk
dc.contributor.authorAksu, Kenan
dc.contributor.authorErtunc, Baris
dc.contributor.authorKorten, Volkan
dc.contributor.authorCeylan, Bahadir
dc.contributor.authorMert, Ali
dc.date.accessioned2019-10-27T10:03:03Z
dc.date.available2019-10-27T10:03:03Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractHemophagocytic Lymphohistiocytosis (HLH) is an indicator of an exaggerated immune response and eventually adverse outcomes. This study aimed to investigate the clinical and laboratory features and outcomes of patients with HLH. The medical records of 26 HLH adult patients (>= 16 years of age) were retrospectively analyzed. Gender, age, the duration of fever, time to diagnosis, etiology and laboratory data were extracted from the records. The mean age was 38 +/- 18 years, and 15 (58%) patients were female. A total of nine cases had infectious diseases; four cases had rheumatologic diseases, three cases had hematological malignancies while nine cases could not have a definitive diagnosis. The median time to detection of HLH was 20 days (IQR: 8-30 d). Of the 25 patients, 11 (44%) died. The erythrocyte sedimentation rates of the surviving and non-surviving patients were 39 +/- 22 mm/h and 15 +/- 13 mm/h, respectively. When a long-lasting fever is complicated by bicytopenia or pancytopenia (especially), clinicians should promptly consider the possibility of HLH syndrome to improve patients' prognosis.en_US
dc.identifier.doi10.4084/MJHID.2018.047en_US
dc.identifier.issn2035-3006
dc.identifier.pmid30210740en_US
dc.identifier.urihttps://doi.org/10.4084/MJHID.2018.047
dc.identifier.urihttps://hdl.handle.net/11454/30066
dc.identifier.volume10en_US
dc.identifier.wosWOS:000443683300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPagepress Publen_US
dc.relation.ispartofMediterranean Journal of Hematology and Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHemophagocytic lymphohistiocytosisen_US
dc.subjectFerritinen_US
dc.subjectCytopeniaen_US
dc.subjectFever of unknown originen_US
dc.titleHemophagocytic Lymphohistiocytosis in Adults: Low Incidence of Primary Neoplasm as a Trigger in a Case Series from Turkeyen_US
dc.typeArticleen_US

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