Functional dyspepsia: relationship between clinical subgroups and Helicobacter pylori status in Western Turkey

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dc.contributor.authorSaruc, M
dc.contributor.authorOzden, N
dc.contributor.authorTurkel, N
dc.contributor.authorAyhan, S
dc.contributor.authorDemir, MA
dc.contributor.authorTuzcuoglu, I
dc.contributor.authorAkarca, US
dc.contributor.authorYuceyar, H
dc.date.accessioned2019-10-27T18:39:19Z
dc.date.available2019-10-27T18:39:19Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.descriptionWorld Congress of Gastroenterology -- FEB 24-MAR 01, 2002 -- BANGKOK, THAILANDen_US
dc.description.abstractThe etiology of functional dyspepsia is not known. The objective of the present study was to determine the characteristics of functional dyspepsia in Western Turkey. We divided 900 patients with functional dyspepsia into three subgroups according to symptoms: ulcer-like (UL), 321 (35.6%), motility disorder-like (ML), 281 (31.2%), and the combination (C) of these symptoms, 298 (33.1%). All patients were submitted to endoscopic evaluation, with two biopsies taken from the cardia and corpus, and four from the antrum of the stomach. All biopsy samples were studied for Helicobacter pylori (Hp) density, chronic inflammation, activity, intestinal metaplasia, atrophy, and the presence of lymphoid aggregates by histological examination. One antral biopsy was used for the rapid urease test. Tissue cagA status was determined by PCR from an antral biopsy specimen by a random sampling method. We also determined the serum levels of tumor necrosis factor-alpha (TNF-alpha) and gastrin by the same method. Data were analyzed statistically by the Kolmogorov-Smimov test and by analysis of variance. Hp and cagA positivity was significantly higher in the UL subgroup than in the others. The patients in the ML subgroup had the lowest Hp and cagA positivity and Hp density. The ML subgroup also showed the lowest level of Hp-induced inflammation among all subgroups. The serum levels of TNF-alpha and gastrin did not reveal any difference between groups. Our findings show a poor association of Hp with the ML subgroup of functional dyspepsia, but a stronger association with the UL and C subgroups.en_US
dc.identifier.doi10.1590/S0100-879X2003000600010en_US
dc.identifier.endpage751en_US
dc.identifier.issn0100-879X
dc.identifier.issue6en_US
dc.identifier.pmid12792704en_US
dc.identifier.startpage747en_US
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2003000600010
dc.identifier.urihttps://hdl.handle.net/11454/36749
dc.identifier.volume36en_US
dc.identifier.wosWOS:000183866400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectfunctional dyspepsiaen_US
dc.subjectsubgroupsen_US
dc.subjectHelicobacter pylorien_US
dc.subjectsymptomsen_US
dc.titleFunctional dyspepsia: relationship between clinical subgroups and Helicobacter pylori status in Western Turkeyen_US
dc.typeArticleen_US

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