Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome

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dc.contributor.authorCalan, Mehmet
dc.contributor.authorYilmaz, Ozgur
dc.contributor.authorKume, Tuncay
dc.contributor.authorKocabas, Gokcen Unal
dc.contributor.authorSenses, Pinar Yesil
dc.contributor.authorSenses, Yasar Mehmet
dc.contributor.authorTemur, Muzaffer
dc.contributor.authorCalan, Ozlem Gursoy
dc.date.accessioned2019-10-27T23:09:20Z
dc.date.available2019-10-27T23:09:20Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBetatrophin is a newly identified hormone determined to be a potent inducer of pancreatic beta cell proliferation in response to insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence is available indicating whether betatrophin is involved in women with PCOS. The objective of this study was to ascertain whether betatrophin levels are altered in women with PCOS. This study was conducted in secondary referral center. This cross-sectional study included 164 women with PCOS and 164 age- and BMI-matched female controls. Circulating betatrophin levels were measured using ELISA. Metabolic and hormonal parameters were also determined. Circulating betatrophin levels were significantly elevated in women with PCOS compared with controls (367.09 +/- 55.78 vs. 295.65 +/- 48.97 pg/ml, P < 0.001). Betatrophin levels were positively correlated with insulin resistance marker homeostasis model assessment of insulin resistance (HOMA-IR), free-testosterone, high-sensitivity C-reactive protein (hs-CRP), atherogenic lipid profiles, and BMI in PCOS. Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 2.51 for patients in the highest quartile of betatrophin compared with those in the lowest quartile (95 % CI 1.31-4.81, P = 0.006). Multivariate regression analyses showed that HOMA-IR, hs-CRP, and free-testosterone were independent factors influencing serum betatrophin levels. Betatrophin levels were increased in women with PCOS and were associated with insulin resistance, hs-CRP, and free-testosterone in these patients. Elevated betatrophin levels were found to increase the odds of having PCOS. Further research is needed to elucidate the physiologic and pathologic significance of our findings.en_US
dc.identifier.doi10.1007/s12020-016-0875-zen_US
dc.identifier.endpage279en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue1en_US
dc.identifier.pmid26832343en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-016-0875-z
dc.identifier.urihttps://hdl.handle.net/11454/52613
dc.identifier.volume53en_US
dc.identifier.wosWOS:000377934000030en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectBetatrophinen_US
dc.subjectInsulin resistanceen_US
dc.subjectFree-testosteroneen_US
dc.subjectLipidsen_US
dc.titleElevated circulating levels of betatrophin are associated with polycystic ovary syndromeen_US
dc.typeArticleen_US

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