Gold nanoparticle conjugated poly(p-phenylene-?-cyclodextrin)-graft-poly(ethylene glycol) for theranostic applications

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dc.contributor.authorBarlas F.B.
dc.contributor.authorAydindogan E.
dc.contributor.authorArslan M.
dc.contributor.authorTimur S.
dc.contributor.authorYagci Y.
dc.date.accessioned2021-05-03T20:48:23Z
dc.date.available2021-05-03T20:48:23Z
dc.date.issued2019
dc.description.abstractFluorescent conjugated polymers gained interest in the last decades for both imaging and targeting tumor cells for the purpose of diagnosis and treatment of cancer. In the light of this objective conjugated poly(p-phenylene) possessing ?-cyclodextrin (?-CD) units in the main chain and poly(ethylene glycol) side chains is used as an imaging and therapeutic agent to target U87 and Vero cells. Additionally, imaging quality and therapy efficiency of the bare graft copolymer and its gold nanoparticle (AuNP) conjugated form were investigated and compared. It is observed that ?-CD is effective not only for the imaging of the tumor cells, but also as a radiotherapy agent. Conjugation of the polymer with the AuNPs provides significant improvement in the therapeutic efficiency. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47250. © 2018 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/app.47250
dc.identifier.issn0021-8995
dc.identifier.issn0021-8995en_US
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85055929265en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/app.47250
dc.identifier.urihttps://hdl.handle.net/11454/70860
dc.identifier.volume136en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiomaterialsen_US
dc.subjectbiomimeticen_US
dc.subjectsensors and actuatorsen_US
dc.titleGold nanoparticle conjugated poly(p-phenylene-?-cyclodextrin)-graft-poly(ethylene glycol) for theranostic applicationsen_US
dc.typeArticleen_US

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