Gold nanoparticle conjugated poly(p-phenylene-?-cyclodextrin)-graft-poly(ethylene glycol) for theranostic applications
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Fluorescent conjugated polymers gained interest in the last decades for both imaging and targeting tumor cells for the purpose of diagnosis and treatment of cancer. In the light of this objective conjugated poly(p-phenylene) possessing ?-cyclodextrin (?-CD) units in the main chain and poly(ethylene glycol) side chains is used as an imaging and therapeutic agent to target U87 and Vero cells. Additionally, imaging quality and therapy efficiency of the bare graft copolymer and its gold nanoparticle (AuNP) conjugated form were investigated and compared. It is observed that ?-CD is effective not only for the imaging of the tumor cells, but also as a radiotherapy agent. Conjugation of the polymer with the AuNPs provides significant improvement in the therapeutic efficiency. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47250. © 2018 Wiley Periodicals, Inc.
Açıklama
Anahtar Kelimeler
biomaterials, biomimetic, sensors and actuators
Kaynak
Journal of Applied Polymer Science
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
136
Sayı
12
