Leukapheresis in Childhood Acute Leukemias: Single-Center Experience

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dc.contributor.authorYilmaz, Deniz
dc.contributor.authorKarapinar, Bulent
dc.contributor.authorKaradas, Nihal
dc.contributor.authorDuyu, Muhterem
dc.contributor.authorYazici, Pinar
dc.contributor.authorAy, Yilmaz
dc.contributor.authorBalkan, Can
dc.contributor.authorAydinok, Yesim
dc.contributor.authorKavakli, Kaan
dc.date.accessioned2019-10-27T22:15:19Z
dc.date.available2019-10-27T22:15:19Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractHyperleukocytosis in patients with leukemia is associated with early mortality, especially due to the pulmonary and neurological complications of leukostasis. The prompt use of leukapheresis may improve patients' survival in the initial treatment period. The medical records of all previously untreated acute leukemia patients were reviewed to determine whether there was hyperleukocytosis at presentation. This study summarizes a single-center experience of leukapheresis that was applied to 12 children with acute leukemia and hyperleukocytosis. The median leukocyte count at diagnosis was 589,000/mm(3) (range: 389,000-942,000/mm(3)) for ALL patients and 232,000/mm(3) (range: 200,000-282,000/mm(3)) for AML patients. A central venous catheter (CVC) was inserted, and leukapheresis procedures were repeated at 12-hour intervals. A total of 29 leukapheresis cycles were performed on 12 children. The median number of cycles of leukapheresis required by each patient was two (range: 1-4). The median absolute and percentage reductions in white blood cell (WBC) count after the first cycle of leukapheresis were 113,000/mm(3) (range: 55,000-442,000/mm(3)) and 36% (range: 16-57.4%), respectively. As a laboratory finding, mild hypocalcemia was the most frequently observed complication. No patients developed any other problem related to the procedure. Our results showed that leukapheresis is a safe and effective procedure if performed by experienced staff.en_US
dc.identifier.doi10.3109/08880018.2013.818747en_US
dc.identifier.endpage326en_US
dc.identifier.issn0888-0018
dc.identifier.issn1521-0669
dc.identifier.issue4en_US
dc.identifier.pmid23988130en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage318en_US
dc.identifier.urihttps://doi.org/10.3109/08880018.2013.818747
dc.identifier.urihttps://hdl.handle.net/11454/50156
dc.identifier.volume31en_US
dc.identifier.wosWOS:000335379100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofPediatric Hematology and Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectALLen_US
dc.subjectAMLen_US
dc.subjectchildrenen_US
dc.subjecthyperleukocytosisen_US
dc.subjectleukapheresisen_US
dc.titleLeukapheresis in Childhood Acute Leukemias: Single-Center Experienceen_US
dc.typeArticleen_US

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