Intraoperative Parathyroid Hormone Monitoring Corroborates the Success of Parathyroidectomy in Children

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dc.contributor.authorCelik, Ahmet
dc.contributor.authorDivarci, Emre
dc.contributor.authorDokumcu, Zafer
dc.contributor.authorErgun, Orkan
dc.contributor.authorOzen, Samim
dc.contributor.authorGoksen, Damla
dc.contributor.authorDarcan, Sukran
dc.contributor.authorErtan, Yesim
dc.date.accessioned2019-10-27T22:13:11Z
dc.date.available2019-10-27T22:13:11Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To assess the efficacy of intraoperative parathyroid hormone (PTH) monitoring in evaluating the outcome of parathyroidectomy in pediatric patients. Methods: Intraoperative PTH monitoring during parathyroidectomy was performed in five children (3M, 2F); three had parathyroid adenomas (single gland disease) and two had primary hyperplasia. One patient had undergone two previous surgical interventions to remove the parathyroid glands, but the PTH levels had remained high with persistence of symptoms. Immunoradiometric analysis was used for PTH measurements. Preoperative PTH values were obtained to monitor the baseline levels. Serum samples were collected 20 minutes after removal of the adenoma/parathyroid gland(s) and PTH levels were compared with preoperative values. Specimens were also confirmed by frozen sectional examination. Results: Mean age of the patients was 11 years (range: 3 months-16 years). Mean preoperative PTH values were 633.3+/-579 pg/mL (range: 143-1300 pg/mL). Intraoperative values decreased to 18.7+/-5.5 pg/mL (range: 8-27 pg/mL) following removal of the gland(s). Normal calcium levels were achieved with adequate management following surgery. One patient (with multiple surgeries and found to have an ectopic parathyroid gland) had hungry bone syndrome after the operation and was treated successfully. There were no major complications. All patients maintained normal calcium/phosphorus levels in the follow-up period, ranging from 2 to 5 years. Conclusion: An ectopic parathyroid gland or another undetected adenoma can be overlooked during surgery. Owing to the short life of the hormone, intraoperative PTH monitoring to determine PTH clearance proved to be a feasible marker for adequacy and safety of surgery and "cure".en_US
dc.identifier.doi10.4274/jcrpe.1401en_US
dc.identifier.endpage162en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue3en_US
dc.identifier.pmid25241609en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.1401
dc.identifier.urihttps://hdl.handle.net/11454/49719
dc.identifier.volume6en_US
dc.identifier.wosWOS:000347784500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParathyroid hormoneen_US
dc.subjecthyperparathyroidismen_US
dc.subjectparathyroid adenomaen_US
dc.subjectparathyroidectomyen_US
dc.titleIntraoperative Parathyroid Hormone Monitoring Corroborates the Success of Parathyroidectomy in Childrenen_US
dc.typeArticleen_US

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