Study on the role of urine gamma-glutamyl transpeptidase activity during investigation of nephrotoxicity

Basit Öğe Kaydı
dc.contributor.authorKocaoglu S.
dc.contributor.authorBerkan T.
dc.contributor.authorKaran A.
dc.contributor.authorBasdemir G.
dc.date.accessioned2019-10-27T00:33:28Z
dc.date.available2019-10-27T00:33:28Z
dc.date.issued1994
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, gamma-glutamyl transpeptidase activities of the 24 h urine samples taken at the end of the fourth day from the rats to which 160 mg/kg/day gentamicin was applied i.p. for 4 days, were measured. Glucose determination in urine by the use of the glucose hexokinase method was also applied in order to control the reabsorption potentials of the tubules. The formation of necrosis in the kidneys was investigated by histological examinations of the damage occurred by the nephrotic effect. All the results were compared with the values obtained from the control group. The average gamma-glutamyl transpeptidase activity for the control group (n = 22) was determined as 5.68 ± 0.26 IU/24 h whereas this level was detected as 15.6 ± 1.0 IU/24 h in the drug applied group (n = 15). The measurement of gamma-glutamyl transpeptidase activity in urine can be applied as a useful parameter on determination of nephrotoxicity, especially for indicating the dimensions of this toxic effect.en_US
dc.identifier.endpage127en_US
dc.identifier.issn0004-069X
dc.identifier.issue2en_US
dc.identifier.pmid7503645en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://hdl.handle.net/11454/24062
dc.identifier.volume42en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofArchivum Immunologiae et Therapiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgamma-glutamyl transpeptidaseen_US
dc.subjectgentamicinen_US
dc.subjectnephrotoxicityen_US
dc.titleStudy on the role of urine gamma-glutamyl transpeptidase activity during investigation of nephrotoxicityen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu