Association between serum vitamin D levels and neuropathic pain in rheumatoid arthritis patients: A cross-sectional study

Basit Öğe Kaydı
dc.contributor.authorYesil, Hilal
dc.contributor.authorSungur, Ulas
dc.contributor.authorAkdeniz, Sedef
dc.contributor.authorGurer, Gulcan
dc.contributor.authorYalcin, Basak
dc.contributor.authorDundar, Umit
dc.date.accessioned2019-10-27T10:43:11Z
dc.date.available2019-10-27T10:43:11Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Recent literature suggests that neuropathic pain (NP) and vitamin D deficiency can occur concurrently in patients with rheumatoid arthritis (RA). This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D. Methods: We used the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) questionnaire to evaluate NP in 93 patients with RA. Demographic and clinical data were obtained from patient files and interviews, and patients' serum vitamin D levels were recorded. Patients were requested to complete both the Short Form-36 survey and the Health Assessment Questionnaire. Results: Seventy-five of the eligible patients were female (80.6%), and 31 (33.3%) were diagnosed with NP according to the LANSS. There was a negative correlation between vitamin D levels and the LANSS score (P = 0.001). The prevalence of NP was 5.8 times higher among patients with serum vitamin D levels below 20 ng/mL than in patients with vitamin D levels >= 30 ng/mL. Based on the area under curve (AUC) values, we found that serum levels of vitamin D were a good predictor of NP diagnoses in patients with RA (AUC = 0.71). Conclusion: We found that vitamin D deficiency was asssociated with increased NP in patients with RA. Although further research is needed to clarify the association between serum vitamin D levels and NP, our study raises awareness of the need to screen for vitamin D deficiency in RA patients with NP.en_US
dc.identifier.doi10.1111/1756-185X.13160en_US
dc.identifier.endpage439en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue2en_US
dc.identifier.pmid28857474en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage431en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13160
dc.identifier.urihttps://hdl.handle.net/11454/30730
dc.identifier.volume21en_US
dc.identifier.wosWOS:000423817900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLANSSen_US
dc.subjectneuropathic painen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectvitamin Den_US
dc.titleAssociation between serum vitamin D levels and neuropathic pain in rheumatoid arthritis patients: A cross-sectional studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu