Progesterone Receptor Gene Polymorphism in Panic Disorder: Associations with Agoraphobia and Respiratory Subtype of Panic Disorder

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dc.contributor.authorPirildar, Sebnem
dc.contributor.authorBayraktar, Erhan
dc.contributor.authorBerdeli, Afig
dc.contributor.authorKucuk, Onur
dc.contributor.authorAlkin, Tunc
dc.contributor.authorKose, Timur
dc.date.accessioned2019-10-27T21:17:31Z
dc.date.available2019-10-27T21:17:31Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: A number of different gene polymorphisms have been found to be involved in the predisposition to development of panic disorder (PD). Previous studies showed that progesterone might play an important role in the psychophysiology of PD. The aim of this study was to investigate the relationship between two different progesterone receptor gene polymorphisms and agoraphobia, nocturnal panic attacks, and respiratory subtype of PD. Methods: Ninety-eight patients diagnosed with PD and 129 healthy controls participated in the study. Patients with PD were divided into two groups on the basis of their symptom profile: respiratory and nonrespiratory subtypes. Seventy-six of 98 patients with PD (79.6%) were in respiratory subtype (RS) of PD. Results: The association between G331A polymorphism and PD in both sexes was significant (p=0.02; OR=2.291; CI=1.141-4.6). PROGINS Alu gene polymorphism was associated with PD in women (p=0.036; OR=0,46; CI=0,219-0.951. It has been also found an assocaition between PROGINS Alu polymorphism and agoraphobia (p=0.002; OR=3.8; CI=1.65-8.76). Conclusion: Our results suggest that the progesterone receptor gene polymorphism might be a susceptibility factor for PD.en_US
dc.identifier.endpage159en_US
dc.identifier.issn1017-7833
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://hdl.handle.net/11454/43830
dc.identifier.volume20en_US
dc.identifier.wosWOS:000281789700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKure Iletisim Grubu A Sen_US
dc.relation.ispartofKlinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneticen_US
dc.subjectpanic disorderen_US
dc.subjectprogesterone receptor polymorphismen_US
dc.subjectrespiratory subtypeen_US
dc.subjectagoraphobiaen_US
dc.titleProgesterone Receptor Gene Polymorphism in Panic Disorder: Associations with Agoraphobia and Respiratory Subtype of Panic Disorderen_US
dc.typeArticleen_US

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