Effects of nicardipine on collar-induced intimal thickening and vascular reactivity in the rabbit

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dc.contributor.authorKerry, Z
dc.contributor.authorYasa, M
dc.contributor.authorAkpinar, R
dc.contributor.authorSevin, G
dc.contributor.authorYetik, G
dc.contributor.authorTosun, M
dc.contributor.authorOzdemir, N
dc.contributor.authorErhan, Y
dc.contributor.authorUstunes, L
dc.contributor.authorOzer, A
dc.date.accessioned2019-10-27T11:50:51Z
dc.date.available2019-10-27T11:50:51Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractThe effects of nicardipine treatment on collar-induced intimal thickening and on accompanying reactivity changes in rabbit carotid artery have been investigated. Treatment for three weeks with subcutaneous nicardipine (20 mg kg(-1) per day) significantly inhibited the intimal thickening caused by perivascular application of a silicone rubber collar. Potassium chloride (KCl), phenylephrine and 5-hydroxytryptamine (5-HT) induced concentration-dependent contractions in both sham-operated and collared arteries. Collar-induced attenuation of maximum KCl-, phenylephrine- and 5-HT-induced contraction was not affected by nicardipine. Collaring caused the means of pot values (the negative logarithm of EC50 values, 50% effective concentration) of 5-HT and phenylephrine to increase and decrease, respectively. Nicardipine did not affect the altered sensitivity to these agonists. Neither collar implantation nor nicardipine treatment altered the pD(2) values for acetylcholine- and nitroglycerine-induced relaxations. These results demonstrate that nicardipine inhibits collar-induced intimal thickening in rabbit carotid artery without affecting the accompanying changes in vascular reactivity, indicating a possible lack of association between the development of intimal thickening and altered reactivity.en_US
dc.identifier.doi10.1211/0022357991772493en_US
dc.identifier.endpage447en_US
dc.identifier.issn0022-3573
dc.identifier.issue4en_US
dc.identifier.pmid10385217en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage441en_US
dc.identifier.urihttps://doi.org/10.1211/0022357991772493
dc.identifier.urihttps://hdl.handle.net/11454/34401
dc.identifier.volume51en_US
dc.identifier.wosWOS:000080655700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Pharmaceutical Soc Great Britainen_US
dc.relation.ispartofJournal of Pharmacy and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffects of nicardipine on collar-induced intimal thickening and vascular reactivity in the rabbiten_US
dc.typeArticleen_US

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