The Effectiveness of the Liquid-Based Preparation Method in Cerebrospinal Fluid Cytology

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dc.contributor.authorArgona, Asuman
dc.contributor.authorUyaroglu, Mehmet Ali
dc.contributor.authorNart, Deniz
dc.contributor.authorVeral, Ali
dc.contributor.authorKitapcioglu, Gul
dc.date.accessioned2019-10-27T21:54:37Z
dc.date.available2019-10-27T21:54:37Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Since malignant cells were first detected in the cerebrospinal fluid (CSF), numerous methods have been used for CSF examination. The cytocentrifugation and liquid-based cytology (LBC) methods are two of these. We aimed to investigate whether the results from the LBC method were different from the results of the cytological diagnosis of the CSF materials that were prepared using the cytocentrifugation method. Materials and Methods: A retrospective analysis was conducted using the pathological records of 3,491 (cytocentrifugation on 1,306 and LBC on 2,185) cytological specimens of CSF which were diagnosed over a 4-year period between January 2007 and December 2011. The Fisher exact test was used to compare the results of the LBC and cytocentrifugation methods. Results: While there was a noticeable decrease in nondiagnostic diagnosis and a slight decrease in suspicious diagnosis, there was an increase in malignant and benign diagnosis with the LBC method in comparison to the centrifugation method. Statistically, the decrease in nondiagnostic diagnosis was considered significant (p < 0.0001). Discussion: The LBC method seems like a better option than the cytocentrifugation method, because of many preparatory, screening and diagnostic advantages, especially in pathology departments where materials come from far away and large volumes are examined. Copyright (c) 2013 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000346716en_US
dc.identifier.endpage270en_US
dc.identifier.issn0001-5547
dc.identifier.issue3en_US
dc.identifier.pmid23636078en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage266en_US
dc.identifier.urihttps://doi.org/10.1159/000346716
dc.identifier.urihttps://hdl.handle.net/11454/48107
dc.identifier.volume57en_US
dc.identifier.wosWOS:000319846100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofActa Cytologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCerebrospinal fluiden_US
dc.subjectCytocentrifugationen_US
dc.subjectLiquid-based cytologyen_US
dc.titleThe Effectiveness of the Liquid-Based Preparation Method in Cerebrospinal Fluid Cytologyen_US
dc.typeArticleen_US

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