Comparison of hematologic toxicity between 3DCRT and IMRT planning in cervical cancer patients after concurrent chemoradiotherapy: a national multi-center study

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dc.contributor.authorErpolat, O. P.
dc.contributor.authorAlco, G.
dc.contributor.authorCaglar, H. B.
dc.contributor.authorIgdem, S.
dc.contributor.authorSaran, A.
dc.contributor.authorDagoglu, N.
dc.contributor.authorAslay, I.
dc.contributor.authorOzsaran, Z.
dc.contributor.authorDemirci, S.
dc.contributor.authorKeven, E.
dc.contributor.authorGuney, Y.
dc.contributor.authorAkmansu, M.
dc.contributor.authorKilic, D.
dc.contributor.authorBayman, E.
dc.contributor.authorEtiz, D.
dc.contributor.authorMandel, N. M.
dc.date.accessioned2019-10-27T22:05:45Z
dc.date.available2019-10-27T22:05:45Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To compare the incidence and severity of acute and chronic hematologic toxicity (HT) in patients treated with three-dimensional conformal radiotherapy (3DCRT) and intensity modulated radiotherapy (IMRT) for curative treatment of cervical cancer and to ascertain the dosimetric parameters of two techniques associated with acute and chronic HT. Materials and Methods: A total of 127 patients with cervical cancer receiving concomitant pelvic radiotherapy (RT) and cisplatin were evaluated. Pelvic bone marrow (BM) was contoured for each patient and divided into five sub-regions: lumbosacrum (LS), ilium (IL), lower pelvis (LP), pelvis (P), and whole pelvis (WP). The volume of each BM region receiving 10,20,30, and 40 Gy was calculated (V10, -V20, -V30, and -V40). The lowest level of hemoglobin, leukocyte, neutrophil, and platelet counts were obtained during chemoradiotherapy and six months after RT. The nadir values were graded according to Common Terminology Criteria for Adverse Events (version 3.0). Results: Grade 2 or greater acute anemia, leukopenia, neutropenia, thrombocytopenia was observed in 2%, 41.5%, 12%,and 0% in 3DCRT group and in 27%, 53%, 24.5%, and 4.5% in IMRT group, respectively. Grade 2 or greater chronic anemia, leukopenia, neutropenia, and thrombocytopenia was observed in 11%, 10%, 6%, and 0% in 3DCRT group and in 11%, 9%, 4.5%, and 0% in IMRT group, respectively. LS-V30,40; IL-V10,20,30,40; LP-V10,20,40; P-V10,20,30,40, and TP-V10,20,30,40 were significantly reduced with IMRT planning compared to 3DCRT planning. Logistic regression analysis of potential predictors showed that none of the dosimetric parameters were significant for predicting acute and chronic HT. Conclusion: The present findings showed that IMRT planning reduced irradiated BM volumes compared to 3DCRT planning. However, no difference between the two techniques was observed in terms of acute and chronic HT. Further studies are needed to confirm these results.en_US
dc.identifier.endpage66en_US
dc.identifier.issn0392-2936
dc.identifier.issue1en_US
dc.identifier.pmid24654465en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://hdl.handle.net/11454/48582
dc.identifier.volume35en_US
dc.identifier.wosWOS:000341554300015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematologic toxicityen_US
dc.subjectCervical canceren_US
dc.subjectRadiotherapyen_US
dc.subjectChemotherapyen_US
dc.titleComparison of hematologic toxicity between 3DCRT and IMRT planning in cervical cancer patients after concurrent chemoradiotherapy: a national multi-center studyen_US
dc.typeArticleen_US

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