Nanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on cancer

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dc.authoridUlucan Karnak, Dr. Fulden/0000-0001-5567-0261
dc.authoridSargazi, Saman/0000-0002-2255-5977
dc.authoridfathi karkan, sonia/0000-0002-1712-9367
dc.contributor.authorDavodabadi, Fatemeh
dc.contributor.authorMirinejad, Shekoufeh
dc.contributor.authorMalik, Sumira
dc.contributor.authorDhasmana, Archna
dc.contributor.authorUlucan-Karnak, Fulden
dc.contributor.authorSargazi, Sara
dc.contributor.authorSargazi, Saman
dc.date.accessioned2024-08-31T07:50:28Z
dc.date.available2024-08-31T07:50:28Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThe long noncoding RNAs (lncRNAs) comprise a wide range of RNA species whose length exceeds 200 nucleotides, which regulate the expression of genes and cellular functions in a wide range of organisms. Several diseases, including malignancy, have been associated with lncRNA dysregulation. Due to their functions in cancer development and progression, lncRNAs have emerged as promising biomarkers and therapeutic targets in cancer diagnosis and treatment. Several studies have investigated the anti-cancer properties of lncRNAs; however, only a few lncRNAs have been found to exhibit tumor suppressor properties. Furthermore, their length and poor stability make them difficult to synthesize. Thus, to overcome the instability of lncRNAs, poor specificity, and their off-target effects, researchers have constructed nanocarriers that encapsulate lncRNAs. Recently, translational medicine research has focused on delivering lncRNAs into tumor cells, including cancer cells, through nano-drug delivery systems in vivo. The developed nanocarriers can protect, target, and release lncRNAs under controlled conditions without appreciable adverse effects. To deliver lncRNAs to cancer cells, various nanocarriers, such as exosomes, microbubbles, polymer nanoparticles, 1,2-dioleyl-3-trimethylammoniumpropane chloride nanocarriers, and virus-like particles, have been successfully developed. Despite this, every nanocarrier has its own advantages and disadvantages when it comes to delivering nucleic acids effectively and safely. This article examines the current status of nanocarriers for lncRNA delivery in cancer therapy, focusing on their potential to enhance cancer treatment. The long noncoding RNAs (lncRNAs) comprise a wide range of RNA species whose length exceeds 200 nucleotides, which regulate the expression of genes and cellular functions in a wide range of organisms.en_US
dc.identifier.doi10.1039/d3nr05656b
dc.identifier.endpage3914en_US
dc.identifier.issn2040-3364
dc.identifier.issn2040-3372
dc.identifier.issue8en_US
dc.identifier.pmid38353296en_US
dc.identifier.scopus2-s2.0-85185501020en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3881en_US
dc.identifier.urihttps://doi.org/10.1039/d3nr05656b
dc.identifier.urihttps://hdl.handle.net/11454/105232
dc.identifier.volume16en_US
dc.identifier.wosWOS:001161736700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofNanoscaleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectSquamous-Cell Carcinomaen_US
dc.subjectEpithelial-Mesenchymal Transitionen_US
dc.subjectVesicle-Mediated Transferen_US
dc.subjectHepatocellular-Carcinomaen_US
dc.subjectCisplatin Resistanceen_US
dc.subjectGene-Expressionen_US
dc.subjectLncrna Meg3en_US
dc.subjectPromotes Angiogenesisen_US
dc.subjectClinical Developmenten_US
dc.subjectEmerging Rolesen_US
dc.titleNanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on canceren_US
dc.typeReview Articleen_US

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