Antimicrobial peptide hCAP-18/LL-37 protein and mRNA expressions in different periodontal diseases

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dc.contributor.authorTurkoglu, O.
dc.contributor.authorKandiloglu, G.
dc.contributor.authorBerdeli, A.
dc.contributor.authorEmingil, G.
dc.contributor.authorAtilla, G.
dc.date.accessioned2019-10-27T21:27:55Z
dc.date.available2019-10-27T21:27:55Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To investigate the levels of antimicrobial peptide hCAP-18/LL-37 protein and mRNA expression in gingival tissues with different periodontal disease. Materials and methods: Ten patients with generalized aggressive periodontitis, 10 patients with chronic periodontitis, and 10 healthy controls were included in this study. Periodontal parameters including probing depth, clinical attachment level, plaque index, and papilla bleeding index were assessed in study subjects. hCAP-18/LL-37 mRNA analysis by RT-PCR and immunohistochemistry were performed in 19 samples provided enough RNA in terms of concentration and integrity. Results: This study demonstrated that hCAP-18/LL-37 was a product of neutrophils. Tissue samples of chronic periodontitis patients had significantly higher immunostaining of hCAP-18/LL-37 on neutrophils infiltrating in both epithelium and connective tissue compared with controls. hCAP-18/LL-37 mRNA expression levels in tissue samples of chronic periodontitis patients seemed to be upregulated compared with controls. While two generalized aggressive periodontitis patients showed downregulated hCAP-18/LL-37 mRNA expression levels, one generalized aggressive periodontitis patient showed slightly increased hCAP-18/LL-37 mRNA level compared with controls. Conclusions: hCAP-18/LL-37 has an important role in innate response during periodontal inflammation. Local deficiency in hCAP-18/LL-37 might be a confounding effect in the pathogenesis of generalized aggressive periodontitis.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-105S463]; Ege University Research FoundationEge University [2007 DIS 022]en_US
dc.description.sponsorshipThis study was supported by grants from The Scientific and Technological Research Council of Turkey (TUBITAK, SBAG-105S463) and Ege University Research Foundation (2007 DIS 022).en_US
dc.identifier.doi10.1111/j.1601-0825.2010.01704.xen_US
dc.identifier.endpage67en_US
dc.identifier.issn1354-523X
dc.identifier.issue1en_US
dc.identifier.pmid20646232en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage60en_US
dc.identifier.urihttps://doi.org/10.1111/j.1601-0825.2010.01704.x
dc.identifier.urihttps://hdl.handle.net/11454/45137
dc.identifier.volume17en_US
dc.identifier.wosWOS:000285250700009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofOral Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperiodontitisen_US
dc.subjectcathelicidin antimicrobial peptideen_US
dc.subjectgene expressionen_US
dc.subjectimmunohistochemistryen_US
dc.titleAntimicrobial peptide hCAP-18/LL-37 protein and mRNA expressions in different periodontal diseasesen_US
dc.typeArticleen_US

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