Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

Basit Öğe Kaydı
dc.authorscopusid58171309000
dc.authorscopusid57210834485
dc.authorscopusid55942313100
dc.authorscopusid55004275200
dc.contributor.authorKeskin, Kaan
dc.contributor.authorEker, Mehmet Cagdas
dc.contributor.authorGonul, Ali Saffet
dc.contributor.authorNorthoff, Georg
dc.date.accessioned2024-08-25T18:48:46Z
dc.date.available2024-08-25T18:48:46Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractMajor depressive disorder (MDD) is a complex mental disorder featured by an increased focus on the self and emotion dysregulation whose interaction remains unclear, though. At the same time, various studies observed abnormal representation of global fMRI brain activity in specifically those regions, e.g., cortical midline structure (CMS) in MDD that are associated with the self. Are the self and its impact on emotion regulation related to global brain activity unevenly represented in CMS relative to non-CMS? Addressing this yet open question is the main goal of our study. We here investigate post-acute treatment responder MDD and healthy controls in fMRI during an emotion task involving both attention and reappraisal of negative and neutral stimuli. We first demonstrate abnormal emotion regulation with increased negative emotion severity on the behavioral level. Next, focusing on a recently established three-layer topography of self, we show increased representation of global fMRI brain activity in specifically those regions mediating the mental (CMS) and exteroceptive (Right temporo-parietal junction and mPFC) self in post-acute MDD during the emotion task. Applying a complex statistical model, namely multinomial regression analyses, we show that increased global infra-slow neural activity in the regions of the mental and exteroceptive self modulates the behavioral measures of specifically negative emotion regulation (emotion attention and reappraisal/suppression). Together, we demonstrate increased representation of global brain activity in regions of the mental and exteroceptive self, including their modulation of negative emotion dysregulation in specifically the infra-slow frequency range (0.01 to 0.1 Hz) of post-acute MDD. These findings support the assumption that the global infra-slow neural basis of the increased self-focus in MDD may take on the role as basic disturbance in that it generates the abnormal regulation of negative emotions.en_US
dc.description.sponsorshipUniversity Medical Research Fund (UMRF), University of Ottawa Brain and Mind Research Institute (UOBMRI); University Medical Research Fund (UMRF); University of Ottawa Brain and Mind Research Institute (UOBMRI); Canadian Institutes of Health Research (CIHR); Physicians' Services Incorporated (PSI) Foundation; CIHR [ES/T01279X/1]; NSERC [ES/T01279X/1]; SHERRC [ES/T01279X/1]; Scientific and Technological Research Council of Turkey [109S134]en_US
dc.description.sponsorshipGN is grateful for funding provided by University Medical Research Fund (UMRF), University of Ottawa Brain and Mind Research Institute (UOBMRI), Canadian Institutes of Health Research (CIHR), and Physicians' Services Incorporated (PSI) Foundation. We are also grateful to CIHR, NSERC, and SHERRC for supporting our tri-council grant from the Canada-UK Artificial Intelligence Initiative The self as agent-environment nexus: crossing disciplinary boundaries to help human selves and anticipate artificial selves (ES/T01279X/1) (together with Karl J. Friston from the UK). This work was supported by The Scientific and Technological Research Council of Turkey (Project Number 109S134).en_US
dc.identifier.doi10.1038/s41398-023-02398-2
dc.identifier.issn2158-3188
dc.identifier.issue1en_US
dc.identifier.pmid37012231en_US
dc.identifier.scopus2-s2.0-85151621306en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41398-023-02398-2
dc.identifier.urihttps://hdl.handle.net/11454/102407
dc.identifier.volume13en_US
dc.identifier.wosWOS:000966698200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofTranslational Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectDefault-Mode Networken_US
dc.subjectStateen_US
dc.subjectResponsesen_US
dc.subjectBrainen_US
dc.titleAbnormal global signal topography of self modulates emotion dysregulation in major depressive disorderen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu