The use of periareolar intradermal Tc-99m tin colloid and peritumoral intraparenchymal isosulfan blue dye injections for determination of the sentinel lymph node

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dc.contributor.authorArgon, Aziz Murat
dc.contributor.authorDuygun, Ulkem
dc.contributor.authorAcar, Ebru
dc.contributor.authorDaglioz, Gozde
dc.contributor.authorYenjay, Levent
dc.contributor.authorZekioglu, Ozman
dc.contributor.authorKapkac, Murat
dc.date.accessioned2019-10-27T19:39:58Z
dc.date.available2019-10-27T19:39:58Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: The purpose of the present study was to evaluate the use of lymphoscintigraphy, blue dye, and gamma probe detection methods for determination of the sentinel lymph node (SLN) using both periareolar intradermal injection of Tc-99m tin colloid and peritumoral intraparenchymal injection of isosulfan blue dye. Methods: One hundred patients with T1-2 breast cancer and clinically negative nodes were enrolled in the present study. The study was composed of 2 groups. Backup axillary lymph node dissection (ALND) was mandatory in group 1 (20 patients) regardless of their lymph node status. In group 2 (80 patients), complete ALND was performed when intraoperative frozen section analysis of SLN revealed metastases. Otherwise, only SLN biopsy was performed without ALND. One day before surgery, Tc-99m tin colloid was injected at 4 periareolar sites intradermally. Lymphoscintigraphy was performed 1 to 2 hours after injection of the radiocolloid. Twenty minutes before surgery, isosulfan blue dye was injected into parenchyma surrounding the tumor or the biopsy cavity. Results: The detection rates of SLN and false-negative rate of lymphoscintigraphy, blue dye, and gamma probe detection were 85%, 95% 100%, and 0% in group 1, 91%, 87%, and 95% in group 2, respectively. Detection rate by the combination of blue dye and radio tracer was 98%. Conclusions: According to the results of our study, we conclude that perioareolar intradermal injection of Tc-99m tin colloid combined with peritumoral intraparenchymal injection of blue dye is an accurate and easy method of locating the sentinel node with very high detection rates. It is recommended that the combination of all methods such as lymphoscintigraphy, blue dye, and gamma probe application will increase the success rate of SLN detection in patients with breast cancer.en_US
dc.identifier.doi10.1097/01.rlu.0000246855.80027.b7en_US
dc.identifier.endpage800en_US
dc.identifier.issn0363-9762
dc.identifier.issn1536-0229
dc.identifier.issue12en_US
dc.identifier.pmid17117076en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage795en_US
dc.identifier.urihttps://doi.org/10.1097/01.rlu.0000246855.80027.b7
dc.identifier.urihttps://hdl.handle.net/11454/40216
dc.identifier.volume31en_US
dc.identifier.wosWOS:000242481400012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofClinical Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgamma probe detectionen_US
dc.subjectsentinel lymph node biopsyen_US
dc.subjectbreast canceren_US
dc.subjectperiareolar injectionen_US
dc.subjectintradermal injectionen_US
dc.titleThe use of periareolar intradermal Tc-99m tin colloid and peritumoral intraparenchymal isosulfan blue dye injections for determination of the sentinel lymph nodeen_US
dc.typeArticleen_US

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