Evaluation of the anti-inflammatory activity of raisins (Vitis vinifera L.) in human gastric epithelial cells: A comparative study

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dc.contributor.authorDi Lorenzo C.
dc.contributor.authorSangiovanni E.
dc.contributor.authorFumagalli M.
dc.contributor.authorColombo E.
dc.contributor.authorFrigerio G.
dc.contributor.authorColombo F.
dc.contributor.authorde Sousa L.P.
dc.contributor.authorAltindisli A.
dc.contributor.authorRestani P.
dc.contributor.authorDell ’ Agli M.
dc.date.accessioned2019-10-27T08:20:30Z
dc.date.available2019-10-27T08:20:30Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractRaisins (Vitis vinifera L.) are dried grapes largely consumed as important source of nutrients and polyphenols. Several studies report health benefits of raisins, including anti-inflammatory and antioxidant properties, whereas the anti-inflammatory activity at gastric level of the hydro-alcoholic extracts, which are mostly used for food supplements preparation, was not reported until now. The aim of this study was to compare the anti-inflammatory activity of five raisin extracts focusing on Interleukin (IL)-8 and Nuclear Factor (NF)-?B pathway. Raisin extracts were characterized by High Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD) analysis and screened for their ability to inhibit Tumor necrosis factor (TNF)?-induced IL-8 release and promoter activity in human gastric epithelial cells. Turkish variety significantly inhibited TNF ? -induced IL-8 release, and the effect was due to the impairment of the corresponding promoter activity. Macroscopic evaluation showed the presence of seeds, absent in the other varieties; thus, hydro-alcoholic extracts from fruits and seeds were individually tested on IL-8 and NF-?B pathway. Seed extract inhibited IL-8 and NF-?B pathway, showing higher potency with respect to the fruit. Although the main effect was due to the presence of seeds, the fruit showed significant activity as well. Our data suggest that consumption of selected varieties of raisins could confer a beneficial effect against gastric inflammatory diseases. © 2016 by the authors; licensee MDPI, Basel, Switzerland.en_US
dc.identifier.doi10.3390/ijms17071156en_US
dc.identifier.issn1661-6596
dc.identifier.issue7en_US
dc.identifier.pmid27447609en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/ijms17071156
dc.identifier.urihttps://hdl.handle.net/11454/25684
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastric inflammationen_US
dc.subjectHPLC-DADen_US
dc.subjectIL-8en_US
dc.subjectNF-?Ben_US
dc.subjectPolyphenolsen_US
dc.subjectRaisinsen_US
dc.titleEvaluation of the anti-inflammatory activity of raisins (Vitis vinifera L.) in human gastric epithelial cells: A comparative studyen_US
dc.typeArticleen_US

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