Early Immunomodulatory Effects of Different Natural Surfactant Preparations in Preterms With Respiratory Distress

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dc.authorscopusid6701464106
dc.authorscopusid55308605000
dc.authorscopusid35390158000
dc.authorscopusid37086922000
dc.authorscopusid6505770201
dc.authorscopusid7004014994
dc.authorscopusid56359518200
dc.contributor.authorYalaz, Mehmet
dc.contributor.authorTanriverdi, Sema
dc.contributor.authorUygur, Ozgun
dc.contributor.authorKoroglu, Ozge Altun
dc.contributor.authorAzarsiz, Elif
dc.contributor.authorAksu, Guzide
dc.contributor.authorKultursay, Nilgun
dc.date.accessioned2023-01-12T20:15:25Z
dc.date.available2023-01-12T20:15:25Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackgroundRespiratory distress syndrome (RDS) is the most common respiratory disease in premature infants. Exogenous natural surfactant preparations are used in the treatment of RDS. In recent years, it has become increasingly evident that surfactant plays an immunoregulatory role. ObjectivesThe aim of this study was to evaluate cytokine and chemokine response following three different regimens of natural surfactant treatment in preterm newborns with RDS. MethodsPremature newborns below 32 weeks of gestation who were intubated for RDS and given early surfactant rescue therapy were included in the study. Newborns were randomly divided into three groups and Beractant 100 mg/kg (B-100), Poractant alfa 100 mg/kg (P alpha-100) and Poractant alfa 200 mg/kg (P alpha-200) were administered intratracheally. Blood samples and transtracheal aspirates (TA) were collected just before and 4-6 h after the surfactant treatment. Total eosinophil count, inducible T Cell alpha chemoattractant (ITaC), macrophage inflammatory protein 3 beta (MIP3b), interleukins (IL) 5, 8, 9, 10, 13, immunoglobulin E (IgE), interferon gamma (IFN-gamma), eotaxin and tumor necrosis factor beta-1 (TGF-beta 1) were measured from blood and tracheal aspirate samples. ResultsA total of 45 infants, 15 in each group, were included in the study. Mean gestational age, birth weight, antenatal, demographic and clinical characteristics of the study groups were similar. IFN gamma concentration and eosinophil counts in TA decreased after surfactant replacement in all groups, especially in the infants treated with P alpha-100 and P alpha-200. Eotaxin, TGF beta and IL-8 concentrations in TA increased significantly in the infants treated with P alpha-100 and P alpha-200. IL-9 levels in TA decreased in the B-100 group but increased in the P alpha-100 and P alpha-200 groups. Blood levels of cytokines and chemokines showed significantly decreased levels of ITaC and MIP3b only in the B-100 group, but no significant change was observed in the P alpha-100 and P alpha-200 groups. ConclusionIn our study, the different immunomodulatory effects of natural surfactant preparations on newborn lung is proven. We found that Poractant alpha, one of the natural surfactant preparations, shifted the lung immune system toward TH2.en_US
dc.description.sponsorshipEge University Scientific Research Projects Unit [MY-13-TIP-030]en_US
dc.description.sponsorshipThis study was carried out with the financial support of the Ege University Scientific Research Projects Unit (MY-13-TIP-030).en_US
dc.identifier.doi10.3389/fped.2022.845780
dc.identifier.issn2296-2360
dc.identifier.pmid35372166en_US
dc.identifier.scopus2-s2.0-85127968899en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fped.2022.845780
dc.identifier.urihttps://hdl.handle.net/11454/78468
dc.identifier.volume10en_US
dc.identifier.wosWOS:000808385200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsurfactanten_US
dc.subjectprematurityen_US
dc.subjectrespiratory distress syndromeen_US
dc.subjectimmune responseen_US
dc.subjectnewbornen_US
dc.subjectProteins Sp-Aen_US
dc.subjectPulmonary Surfactanten_US
dc.subjectBronchopulmonary Dysplasiaen_US
dc.subjectLymphocyte-Proliferationen_US
dc.subjectHuman Monocytesen_US
dc.subjectLung Injuryen_US
dc.subjectSp-Ben_US
dc.subjectInflammationen_US
dc.subjectSusceptibilityen_US
dc.subjectComponentsen_US
dc.titleEarly Immunomodulatory Effects of Different Natural Surfactant Preparations in Preterms With Respiratory Distressen_US
dc.typeArticleen_US

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