MRI assessment of pituitary Iron accumulation by using pituitary-R2 in beta-thalassemia patients

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dc.contributor.authorBozdag, Mustafa
dc.contributor.authorBayraktaroglu, Selen
dc.contributor.authorAydinok, Yesim
dc.contributor.authorCalli, Mehmet Cem
dc.date.accessioned2019-10-27T10:05:38Z
dc.date.available2019-10-27T10:05:38Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Patients with thalassemia major (TM) require repeated blood transfusions, which leads to accumulation of iron in a wide variety of tissues. Accumulation of iron in the pituitary gland can lead to irreversible hypogonadotropic hypogonadism (HH) in this group of patients. Purpose: To investigate the reliability of pituitary-R.2 as a marker to estimate the extent of pituitary iron load by comparing the pituitary magnetic resonance imaging (MRI) findings with hepatic iron load and serum ferritin levels. Material and Methods: A total of 38 beta-TM patients were classified into HH (group A, n = 18) and non-HH (group B, n = 17) groups. A third group, group C, consisted of 17 healthy participants. Each participant underwent 1.5-T MRI examinations. Pituitary gland heights (PGH), pituitary-R2 values, and liver-R2 values were measured by using multi-echo spin-echo sequences. Results: Pituitary-R2 values were significantly higher in group A compared with group B Rho < 0.05). A positive correlation was detected between the pituitary-R2 values and serum ferritin levels in TM patients Rho < 0. 01) A threshold value of 14.1 Hz for pituitary-R2 was found to give a high specificity and sensitivity in distinguishing the TM patients with HH from those with normal pituitary functions. PGH measurements were significantly lower in group A compared with group B Rho < 0.05). Conclusion: MRI-assessed pituitary-R2 seems to be a reliable marker for differentiating the TM patients with normal pituitary function from those with secondary hypogonadism due to iron toxicity.en_US
dc.identifier.doi10.1177/0284185117730099en_US
dc.identifier.endpage739en_US
dc.identifier.issn0284-1851
dc.identifier.issn1600-0455
dc.identifier.issue6en_US
dc.identifier.pmid28882060en_US
dc.identifier.startpage732en_US
dc.identifier.urihttps://doi.org/10.1177/0284185117730099
dc.identifier.urihttps://hdl.handle.net/11454/30374
dc.identifier.volume59en_US
dc.identifier.wosWOS:000432868300016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofActa Radiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbeta-thalassemiaen_US
dc.subjecthypogonadotropic hypogonadismen_US
dc.subjectiron loaden_US
dc.subjectmagnetic resonance imaging (MRI)en_US
dc.subjectpituitary glanden_US
dc.titleMRI assessment of pituitary Iron accumulation by using pituitary-R2 in beta-thalassemia patientsen_US
dc.typeArticleen_US

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