Combined venom profiling and cytotoxicity screening of the Radde's mountain viper (Montivipera raddei) and Mount Bulgar Viper (Montivipera bulgardaghica) with potent cytotoxicity against human A549 lung carcinoma cells

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dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorHempel, Benjamin-Florian
dc.contributor.authorPetras, Daniel
dc.contributor.authorHeiss, Paul
dc.contributor.authorGocmen, Bayram
dc.contributor.authorIgci, Nasit
dc.contributor.authorYildiz, Mehmet Zulfu
dc.contributor.authorSussmuth, Roderich D.
dc.date.accessioned2019-10-27T11:06:19Z
dc.date.available2019-10-27T11:06:19Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractHere we report the first characterization of the endemic Mount Bulgar Viper (Montivipera bulgardaghica) and Radde's mountain viper (Montivipera raddei) venom by a combined approach using intact mass profiling and bottom-up proteomics. The cytotoxicity screening of crude venom as well as isolated serine proteases revealed a high activity against A549 human lung carcinoma cells. By means of intact mass profiling of native and reduced venom we observed basic and acidic phospholipases type A(2). Moreover, the analysis revealed snake venom metalloproteases, cysteine-rich secretory proteins, disintegrins, snake venom serine proteases, C-type lectins, a vascular endothelial growth factor and an L-amino acid oxidase. (C) 2017 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG); Cluster of Excellence Unifying Concepts in Catalysis (UniCat)German Research Foundation (DFG); Scientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [111T338]en_US
dc.description.sponsorshipThis study was supported by the Deutsche Forschungsgemeinschaft (DFG), Cluster of Excellence Unifying Concepts in Catalysis (UniCat) and by the Scientific and Technical Research Council of Turkey (TUBITAK) under Grant 111T338.en_US
dc.identifier.doi10.1016/j.toxicon.2017.06.008en_US
dc.identifier.endpage83en_US
dc.identifier.issn0041-0101
dc.identifier.pmid28625888en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2017.06.008
dc.identifier.urihttps://hdl.handle.net/11454/31833
dc.identifier.volume135en_US
dc.identifier.wosWOS:000407869000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofToxiconen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMontiviperaen_US
dc.subjectMount Bulgar Viperen_US
dc.subjectRadde's mountain viperen_US
dc.subjectSnake venomicsen_US
dc.subjectIntact mass profilingen_US
dc.subjectCytotoxicityen_US
dc.titleCombined venom profiling and cytotoxicity screening of the Radde's mountain viper (Montivipera raddei) and Mount Bulgar Viper (Montivipera bulgardaghica) with potent cytotoxicity against human A549 lung carcinoma cellsen_US
dc.typeArticleen_US

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