Vitamin D deficiency in the absence of enteropathy in three cases with common variable immunodeficiency

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dc.contributor.authorArdeniz, Omur
dc.contributor.authorAvci, Cigir Biray
dc.contributor.authorSin, Aytul
dc.contributor.authorOzgen, Gokhan
dc.contributor.authorGunsar, Fulya
dc.contributor.authorMete, Nihal
dc.contributor.authorGulbahar, Okan
dc.contributor.authorKokuludag, Ali
dc.date.accessioned2019-10-27T19:56:58Z
dc.date.available2019-10-27T19:56:58Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and a defect in antibody production. Herein we describe 3 patients diagnosed with CVID in whom vitamin D deficiency was detected in the absence of enteropathy. Methods: Biochemical and immunological analysis, serum osteocalcin, parathyroid hormone, 25-OH vitamin D, 1,25(OH) 2 vitamin D, vitamin A, vitamin E, urinary calcium, and deoxypyridinoline measurements were carried out. Vitamin D receptor (VDR) expression was examined in the peripheral blood mononuclear cells and hair follicles by reverse transcriptase polymerase chain reaction. VDR gene polymorphism was evaluated by high-performance liquid chromatography. Results: None of the patients presented nutrient deficiencies other than vitamin D. Two of them were free of osteomalacia-related symptoms. VDR expression was found to be lower in the peripheral blood mononuclear cells and hair follicles when compared to the control group. Conclusions: Patients with CVID may present asymptomatic vitamin D deficiency. Vitamin D and VDRs play an important role in the innate immune system and modulate Toll-like receptor-related responses. Delay in diagnosis may predispose these patients not only to irreparable bone loss but also to infections, and autoimmune and malignant disorders, thus emphasizing the importance of prompt intervention. Copyright (C) 2008 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000128661en_US
dc.identifier.endpage83en_US
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.issue1en_US
dc.identifier.pmid18451650en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.1159/000128661
dc.identifier.urihttps://hdl.handle.net/11454/40888
dc.identifier.volume147en_US
dc.identifier.wosWOS:000258707700009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectimmunodeficiencyen_US
dc.subjectimmunomodulationen_US
dc.subjectvitamin D-3en_US
dc.subjectcommon variable immunodeficiencyen_US
dc.subjectvitamin D deficiencyen_US
dc.subjectvitamin D receptor expressionen_US
dc.titleVitamin D deficiency in the absence of enteropathy in three cases with common variable immunodeficiencyen_US
dc.typeArticleen_US

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