Associations of interleukin (IL)-1ß, IL-1 receptor antagonist, and IL-10 with dental caries

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dc.contributor.authorCogulu D.
dc.contributor.authorOnay H.
dc.contributor.authorOzdemir Y.
dc.contributor.authorAslan G.I.
dc.contributor.authorÖzkınay F.
dc.contributor.authorKutukculer N.
dc.contributor.authorEronat C.
dc.date.accessioned2019-10-27T08:21:10Z
dc.date.available2019-10-27T08:21:10Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractStreptococcus mutans is important in dental caries. Although the role of cytokines in the pathogenesis of dental caries is not clear, components of S. mutans were found to stimulate production of pro-inflammatory cytokines. We examined the associations of interleukin (IL)-1ß, IL-1 receptor antagonist (IL-1ra), and IL-10 with dental caries. Unstimulated whole saliva and blood samples were obtained from 108 children aged 6-12 years with high caries (decayed, missing, or filled teeth [dmft/DMFT] index >4, n = 37), moderate caries (dmft/DMFT = 1-4, n = 37), or caries-free (dmft/DMFT = 0, n = 34). S. mutans level was classified as low (<105colony-forming units [CFU]/mL) or high (?105CFU/mL). Saliva and serum concentrations of IL-1ß, IL-1ra, and IL-10 were determined by ELISA. IL-1ß, IL-1ra, and IL-10 gene polymorphisms were genotyped using PCR and restriction fragment length polymorphism analysis. The chi-square, Mann-Whitney U, one-way ANOVA, posthoc, Fisher’s exact, and t tests were used in statistical analysis. Dental caries was not correlated with salivary or serum concentrations of the studied cytokines. S. mutans level positively correlated with saliva IL-1ß concentration and inversely correlated with saliva IL-1ra concentration. There was no correlation of IL-1ß, IL-1ra, or IL-10 gene polymorphisms with dental caries. S. mutans is important in stimulating saliva IL-1ß and inhibiting IL-1ra. Future studies of associations between cytokines and dental caries should investigate additional cytokines and enroll a larger number of participants. © 2015, Journal of Oral Science. All rights reserved.en_US
dc.identifier.doi10.2334/josnusd.57.31en_US
dc.identifier.endpage36en_US
dc.identifier.issn1343-4934
dc.identifier.issue1en_US
dc.identifier.pmid25807906en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.2334/josnusd.57.31
dc.identifier.urihttps://hdl.handle.net/11454/25940
dc.identifier.volume57en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNihon University, School of Dentistryen_US
dc.relation.ispartofJournal of Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDental cariesen_US
dc.subjectIL-10en_US
dc.subjectIL-1raen_US
dc.subjectIL-1ßen_US
dc.subjectStreptococcus mutansen_US
dc.titleAssociations of interleukin (IL)-1ß, IL-1 receptor antagonist, and IL-10 with dental cariesen_US
dc.typeArticleen_US

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