Acute lymphoblastic leykemia in apatient with wilson disease treated with D-pencillamine

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dc.contributor.authorSahin F.
dc.contributor.authorSaydam, G..
dc.contributor.authorSahin O.
dc.contributor.authorOcakci S.
dc.contributor.authorErtan Y.
dc.contributor.authorAkarca U.S.
dc.contributor.authorTombuloglu M.
dc.date.accessioned2019-10-27T00:01:48Z
dc.date.available2019-10-27T00:01:48Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractWilson disease (WD) is a rare inherited disease of copper metabolism, characterized by liver and central nervous system dysfunction. It is usually associated with some other diseases such as autoimmune disorders and malignancies. We hereby report a case with diagnosis of acute lymphoblastic leukemia which developed in the course of WD under the treatment of D-penicillamine. Twenty five years old female patient was diagnosed WD ten years ago. Therapy was started with D-penicillamine, zinc sulfate and a low copper diet has been given during the course of the disease. The disease has been under control for the last ten years. She was admitted to the hospital with complaints of pallor, fatigue, fever and ecchymoses. The diagnosis was acute lymphoblastic leukemia (ALL) according to bone marrow analysis. Although she responded to remission/induction regimen, she relapsed in early period and accepted as refractory disease after 2 cycles of intensive chemotherapy regimen. Coexistence of WD and acute leukemia is very rare phenomenon although genetical and etiological background of these two entities could not be enough for explanation of this co-existence so far. It is also not clearly documented yet whether WD induces leukemia or D-penicillamine could cause additional malignancy. Further investigations are still needed to clarify this situation. Copyright © Hellenic Society of Haematology.en_US
dc.identifier.endpage690en_US
dc.identifier.issn1108-2682
dc.identifier.issn1108-2682en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage688en_US
dc.identifier.urihttps://hdl.handle.net/11454/21576
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofHAEMAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute leukemiaen_US
dc.subjectD-penicillamineen_US
dc.subjectWilson diseaseen_US
dc.titleAcute lymphoblastic leykemia in apatient with wilson disease treated with D-pencillamineen_US
dc.typeArticleen_US

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