Acute lymphoblastic leykemia in apatient with wilson disease treated with D-pencillamine
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Wilson disease (WD) is a rare inherited disease of copper metabolism, characterized by liver and central nervous system dysfunction. It is usually associated with some other diseases such as autoimmune disorders and malignancies. We hereby report a case with diagnosis of acute lymphoblastic leukemia which developed in the course of WD under the treatment of D-penicillamine. Twenty five years old female patient was diagnosed WD ten years ago. Therapy was started with D-penicillamine, zinc sulfate and a low copper diet has been given during the course of the disease. The disease has been under control for the last ten years. She was admitted to the hospital with complaints of pallor, fatigue, fever and ecchymoses. The diagnosis was acute lymphoblastic leukemia (ALL) according to bone marrow analysis. Although she responded to remission/induction regimen, she relapsed in early period and accepted as refractory disease after 2 cycles of intensive chemotherapy regimen. Coexistence of WD and acute leukemia is very rare phenomenon although genetical and etiological background of these two entities could not be enough for explanation of this co-existence so far. It is also not clearly documented yet whether WD induces leukemia or D-penicillamine could cause additional malignancy. Further investigations are still needed to clarify this situation. Copyright © Hellenic Society of Haematology.
Açıklama
Anahtar Kelimeler
Acute leukemia, D-penicillamine, Wilson disease
Kaynak
HAEMA
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
9
Sayı
5
