TAp73 alpha is Upregulated in the Most Common Human Cancers

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dc.authoridSUNER, ASLI/0000-0002-6872-9901
dc.authorwosidSUNER, ASLI/C-1032-2012
dc.contributor.authorIscan, E.
dc.contributor.authorKarakulah, G.
dc.contributor.authorEkin, U.
dc.contributor.authorOzturk, M.
dc.contributor.authorUzuner, H.
dc.contributor.authorSuner, A.
dc.date.accessioned2023-01-12T20:02:54Z
dc.date.available2023-01-12T20:02:54Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThe transcription factor p73 is a member of the p53 tumor suppressor gene family and one of the key regulators of apoptosis. TP73 gene encodes two protein isoforms classes with diverse functions, TAp73 and DNp73, and TAp73 expression in tumor tissues is altered. Unlike the TP53 gene, TP73 is not mutated in cancers. Here, we sought to explore the expression of p73 isoforms across eight major cancer types using the publicly available data deposited at the GDC data portal and the TSVdb database. Our results showed that TAp73 alpha is overexpressed in breast invasive carcinoma, stomach adenocarcinoma, lung squamous cell carcinoma, colon adenocarcinoma, and esophageal carcinoma tumors, whereas the expression of DNp73 isoforms is downregulated in breast invasive carcinoma (DNp73 alpha,beta,gamma), Prostate Adenocarcinoma (DNp73 beta), Lung Adenocarcinoma (DNp73 alpha), Lung Squamous Cell Carcinoma (DNp73 alpha) tumors. In summary, this study revealed that TAp73 alpha has higher expression than the DNp73 isoforms in several cancer types.en_US
dc.description.sponsorshipTUBITAK [113S389]en_US
dc.description.sponsorshipThis work was supported by TUBITAK grant no. 113S389.en_US
dc.identifier.doi10.1134/S0026893322020066
dc.identifier.endpage256en_US
dc.identifier.issn0026-8933
dc.identifier.issn1608-3245
dc.identifier.issue2en_US
dc.identifier.pmid35403622en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://doi.org/10.1134/S0026893322020066
dc.identifier.urihttps://hdl.handle.net/11454/77636
dc.identifier.volume56en_US
dc.identifier.wosWOS:000741637400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofMolecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectp73en_US
dc.subjectcanceren_US
dc.subjectTCGA splicing variants analysisen_US
dc.subjectPoor-Prognosisen_US
dc.subjectP73en_US
dc.subjectP53en_US
dc.subjectDelta-Np73en_US
dc.subjectExpressionen_US
dc.subjectIsoformsen_US
dc.subjectImpacten_US
dc.subjectTap73en_US
dc.subjectGeneen_US
dc.subjectP63en_US
dc.titleTAp73 alpha is Upregulated in the Most Common Human Cancersen_US
dc.typeArticleen_US

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