Soluble P-selectin and the success of thrombolysis in acute myocardial infarction
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: P-Selectin mediates adhesive interactions between platelets, leukocytes and endothelium to forth thrombi. Our purpose was to investigate plasma soluble(s) P-selectin levels in patients with acute myocardial infarction (aMI) and the effect of thrombolysis on P-selectin levels. Methods: Patients with aMI within the first 6 h of chest pain were enrolled prospectively. sP-selectin levels were determined by ELISA in the plasma of patients with aMI (n=32), stable angina (n=18), and healthy controls (n=15). Samples were obtained before, 3 and 24 h after reperfusion therapy with tissue plasminogen activator. Seven patients showed recurrent angina or failure to reperfuse. Results: sP-selectin levels were significantly higher in aMI group than other groups (86.7 +/-8.7 ng/ml, P <0.05). SP-selectin levels were similar in stable angina and control groups (28.8 +/-4.4 vs. 25.4 +/-7.3 ng/ml, P=NS). A significant increase in sP-selectin levels was observed 3 h after successful thrombolysis and this was followed by a decrease to near the baseline level late after reperfusion. But patients with failed reperfusion showed sustained high sP-selectin levels after 24 h of thrombolysis (P <0.05). Conclusion: The plasma sP-selectin level is elevated in aMI and it increases further following thrombolytic therapy. This increase is probably induced by activation of endothelial cells or platelets after myocardial ischemia and reperfusion during aMI. As the elevated levels are sustained in patients with failed reperfusion, serial P-selectin levels may be used as a non-invasive indicator of successful thrombolysis in aMI. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
Açıklama
21st Congress of the European-Society-of-Cardiology -- AUG 28-SEP 01, 1999 -- BARCELONA, SPAIN
Anahtar Kelimeler
acute myocardial infarction, P-selectin, thrombolytic therapy
Kaynak
International Journal of Cardiology
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
79
Sayı
02.Mar
