Association of decreased C1q/tumor necrosis factor- related protein-5 levels with metabolic and hormonal disturbance in polycystic ovary syndrome

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dc.contributor.authorCalan, Mehmet
dc.contributor.authorAlan, Murat
dc.contributor.authorAlarslan, Pinar
dc.contributor.authorKocabas, Gokcen Unal
dc.contributor.authorBozkaya, Giray
dc.contributor.authorAcara, Ahmet Cagdas
dc.contributor.authorAslanipour, Behnaz
dc.contributor.authorFenercioglu, Ozge
dc.contributor.authorIsil, Ahmet Murat
dc.contributor.authorGuler, Asli
dc.date.accessioned2019-10-27T09:44:02Z
dc.date.available2019-10-27T09:44:02Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: C1q/tumor necrosis factor-related protein-5 (CTRP5) is a novel peptide hormone involved in the metabolism of energy regulation. Polycystic ovary syndrome (PCOS), which is a reproductive and metabolic disorder, is associated with insulin resistance. The aim of the current study was to compare circulating levels of CTRP5 in women with and without PCOS and to investigate possible associations between CTRP5 and metabolic-hormonal parameters. Material and Methods: The present cross-sectional study contained 80 women with PCOS and 80 age and body mass index-matched women without PCOS. Circulating levels of CTRP5 were calculated using an enzyme-linked immunosorbent assay. We also measured hormonal and metabolic parameters. Results: Patients with PCOS had lower levels of circulating CTRP5 compared with women without PCOS (6.90 +/- 2.64 vs 11.73 +/- 3.66 ng/mL, p<0.001). CTRP5 was negatively correlated with insulin resistance, free-androgen index, and body mass index in both the PCOS and control groups. Moreover, patients with PCOS who had insulin resistance showed lower circulating CTRP5 levels compared with those without insulin resistance. In both the control and PCOS groups, overweight subjects had lower circulating levels of CTRP5 compared with participants of normal weight. Logistic regression analyses indicated that subjects in the lowest tertile for CTRP5 level had higher risk for PCOS compared with those in the highest tertile of CTRP5. Conclusion: Decreased circulating levels of CTRP5 were associated with higher risk of PCOS, as well as having metabolic disturbance among women with PCOS.en_US
dc.identifier.doi10.4274/jtgga.galenos.2018.2018.0027en_US
dc.identifier.endpage96en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue2en_US
dc.identifier.pmid29964236en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.4274/jtgga.galenos.2018.2018.0027
dc.identifier.urihttps://hdl.handle.net/11454/28949
dc.identifier.volume20en_US
dc.identifier.wosWOS:000469277900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of the Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectC1q/tumor necrosis factor-related protein-5en_US
dc.subjectinsulin resistanceen_US
dc.subjectbody mass indexen_US
dc.subjectfree-androgen indexen_US
dc.titleAssociation of decreased C1q/tumor necrosis factor- related protein-5 levels with metabolic and hormonal disturbance in polycystic ovary syndromeen_US
dc.typeArticleen_US

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