ß1 and ß2-adrenergic receptor polymorphisms and idiopathic ventricular arrhythmias
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Genetics and Idiopathic Ventricular Arrhythmias. Introduction: Idiopathic ventricular arrhythmias commonly refer to ventricular tachycardia (VT) and/or frequent/monomorphic premature ventricular contractions (PVC) in patients with structurally normal heart. Activation of sympathetic tone has been shown to play an important role in the provocation and maintenance of these arrhythmias. We investigated whether common single nucleotide polymorphisms in the ß1 and ß2-adrenergic receptors are associated with idiopathic ventricular arrhythmias. Methods: A total of 143 unrelated patients presenting with idiopathic ventricular arrhythmias were prospectively included in a case-control association study. Patient population was matched by age and gender to the unrelated, healthy control subjects (N = 307). All study subjects were of Turkish (Anatolian Caucasian) descent. Allele and genotype frequencies of the Gly389Arg and Ser49Gly polymorphisms of the ß1-adrenergic receptor and Arg16Gly, Gln27Glu, and Thr164Ile polymorphisms of the ß2-adrenergic receptor were compared between patient population and control subjects. The genotype frequencies were in Hardy-Weinberg equilibrium. Results: Patients with idiopathic ventricular arrhythmias had higher frequency of Arg389Arg genotype (22.4% vs 1.6%, P < 0.001), Arg389Gly49 (5.24% vs 0.73%, P = 0.005), and Arg389Ser49 (36.7% vs 13.6%, P < 0.001) haplotypes of the ß1-adrenergic receptor, and higher frequency of Gly16Gly (31.5% vs 13.4%, P < 0.001), Glu27Glu genotypes (18.2% vs 10.1%, P = 0.006) and Gly16Gln27Thr164 (15.3% vs 7.4%, P = 0.002), Gly16Glu27Thr164 (13.1% vs 7%, P = 0.004), and Gly16Glu27Ile164 (13.2% vs 6%, P = 0.002) haplotypes of the ß2-adrenergic receptor compared to control subjects. Conclusion: Our data suggest that common single nucleotide polymorphisms in the ß1 and ß2- adrenergic receptors are significantly associated with idiopathic ventricular arrhythmias in Turkish population. © 2008 Wiley Periodicals, Inc.
Açıklama
Anahtar Kelimeler
Arrhythmias, Beta adrenergic receptors, Genetics, Tachycardia, Ventricular tachycardia
Kaynak
Journal of Cardiovascular Electrophysiology
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
19
Sayı
10
