Red grape seed extract and its compound resveratrol exert cytotoxic effect to various human cancer lines

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dc.contributor.authorŞahin F.
dc.contributor.authorAvci C.B.
dc.contributor.authorAvcu F.
dc.contributor.authorUral A.U.
dc.contributor.authorSarper M.
dc.contributor.authorHişil Y.
dc.contributor.authorOmay S.B.
dc.contributor.authorSaydam, G..
dc.date.accessioned2019-10-26T23:59:06Z
dc.date.available2019-10-26T23:59:06Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractModern medicinal agents currently available for treatment of cancers are very expensive, toxic, and less effective in treating some of the disease. Thus, one must investigate further in detail the agents derived from natural sources, such as grape seed, for the prevention and treatment of cancer and disease. In recent years interest of researchers has focused on grape seed and nowadays scientists have used extracts of grape seed to treat different health problems including cancer. We examined the cytotoxic effect of red grape seed extract (GSE) and its main compound resveratrol (RES) on different human cancer cell lines representing various solid tumors and hematological malignancies at the same time. Red GSE was prepared by using 1, 1, 1, 2-Tetrafluoroethane extraction method. Cytotoxicity of the extract and RES was evaluated by using trypan blue dye exclusion method and MTT assay. The results of our study show that GSE and RES have cytotoxic activities in varying degree in several cancer cell lines. There has not been any study evaluating the GES and RES in the same cell lines and in the same conditions. But, it is still needed to have more pre-clinical and laboratory studies to validate the usefulness of these agents either alone or in combination with existing therapy. © Turkish Society of Hematology.en_US
dc.identifier.endpage109en_US
dc.identifier.issn1300-7777
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage102en_US
dc.identifier.urihttps://hdl.handle.net/11454/21339
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer cell lineen_US
dc.subjectCytotoxicityen_US
dc.subjectGrape seed extracten_US
dc.subjectResveratrolen_US
dc.titleRed grape seed extract and its compound resveratrol exert cytotoxic effect to various human cancer linesen_US
dc.typeArticleen_US

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