Poly(p-phenylene) with Poly(ethylene glycol) Chains and Amino Groups as a Functional Platform for Controlled Drug Release and Radiotherapy

Basit Öğe Kaydı
dc.contributor.authorGuler, Bahar
dc.contributor.authorAkbulut, Huseyin
dc.contributor.authorBarlas, Firat Baris
dc.contributor.authorGeyik, Caner
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorSenisik, Ahmet Murat
dc.contributor.authorArican, Halil Armagan
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T23:10:05Z
dc.date.available2019-10-27T23:10:05Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractConventional cancer treatments such as chemotherapy, radiotherapy, or combination of these two result in side effects, which lower the quality of life of the patients. To overcome problems with these methods, altering the drug properties by conjugating them to carrier polymers has emerged. Such polymeric carriers also hold the potential to make tumor cells more sensitive to radiation therapy. Herein, poly(p-phenylene) (PPP) polymer with poly(ethylene glycol) (PEG) chains and primary amino groups (PPP-NH2-g-PEG) is synthesized and conjugated with anticancer drug Doxorubicin (DOX). pH dependent drug release experiments are performed at pH 5.3 and pH 7.4, respectively. Cell viability studies on human cervix adenocarcinoma cells show that lower doses of DOX inhibit cell proliferation when conjugated with nontoxic doses of PPP-NH2-g-PEG polymer. Additionally, PPP-NH2-g-PEG/Cys/DOX bioconjugate significantly increases radiosensitive properties of DOX. It is possible to use lower doses of DOX when conjugated to PPP-NH2-g-PEG in combination with radiotherapy.en_US
dc.description.sponsorshipEge UniversityEge University; Aliye USTER Foundationen_US
dc.description.sponsorshipEge University, Aliye USTER Foundation is acknowledged for the financial support. LINAC system was used at SIFA University Hospital (Izmir).en_US
dc.identifier.doi10.1002/mabi.201500384en_US
dc.identifier.endpage737en_US
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.issue5en_US
dc.identifier.pmid26797717en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage730en_US
dc.identifier.urihttps://doi.org/10.1002/mabi.201500384
dc.identifier.urihttps://hdl.handle.net/11454/52819
dc.identifier.volume16en_US
dc.identifier.wosWOS:000376070000010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbioconjugationen_US
dc.subjectdrug releaseen_US
dc.subjectgraft copolymeren_US
dc.subjectpoly(p-phenylene)sen_US
dc.subjectradiosensitivityen_US
dc.titlePoly(p-phenylene) with Poly(ethylene glycol) Chains and Amino Groups as a Functional Platform for Controlled Drug Release and Radiotherapyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu