Biomimetic peptide-conjugated membranes for developing an artificial cornea

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dc.authorscopusid57221559628
dc.authorscopusid58018541700
dc.authorscopusid26648037000
dc.authorscopusid57796997500
dc.authorscopusid8516383700
dc.authorscopusid55804374300
dc.authorscopusid37099855700
dc.contributor.authorSunal G.
dc.contributor.authorPulat G.
dc.contributor.authorAkgün I.H.
dc.contributor.authorGüven S.
dc.contributor.authorYildiz Ü.H.
dc.contributor.authorKaraman O.
dc.contributor.authorHorzum N.
dc.date.accessioned2023-01-12T20:23:21Z
dc.date.available2023-01-12T20:23:21Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description2022 Medical Technologies Congress, TIPTEKNO 2022 -- 31 October 2022 through 2 November 2022 -- -- 184752en_US
dc.description.abstractThe corneal endothelium is composed of a single layer of specialized endothelial cells, protecting, and nourishing the inner surface of the cornea. Corneal endothelial cells do not proliferate after birth and their number decrease with age. Trauma, inflammation, or surgical intervention can cause cell loss. When damage is extensive and the density of corneal endothelial cells decreases to a critical level, it results in corneal edema and vision loss. Besides them, when corneal endothelium has irreversible damage, the only treatment way is corneal transplantation. But there are some drawbacks such as finding donors, immune reactions, and the number of patients waiting on the transplantation lists for years. Tissue engineering approaches can provide promising alternatives for the regeneration of corneal endothelium tissue. Peptides can be used to modify and functionalize the scaffolds, allowing for the production of bioactive and biomimetic surfaces. Peptide-modified scaffold surfaces might direct and enhance the behaviors of cells. In this study, the aim was to functionalize the polycaprolactone (PCL) membranes with tissue-specific peptides and to characterize the peptide-conjugated membranes by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-ray Photoelectron Spectroscopy (XPS) analysis. The synthesized peptides were successfully conjugated on the PCL biomembranes. © 2022 IEEE.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 218S991, 219S989, 318S275en_US
dc.description.sponsorshipACKNOWLEDGMENT The authors thank to the Scientific and Technological Research Council of Turkey (TUBITAK) (1003 Project numbers: 218S991, 219S989, and 318S275).en_US
dc.identifier.doi10.1109/TIPTEKNO56568.2022.9960151
dc.identifier.isbn9781665454322
dc.identifier.scopus2-s2.0-85144007471en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1109/TIPTEKNO56568.2022.9960151
dc.identifier.urihttps://hdl.handle.net/11454/79691
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInstitute of Electrical and Electronics Engineers Inc.en_US
dc.relation.ispartofTIPTEKNO 2022 - Medical Technologies Congress, Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcharacterizationen_US
dc.subjectcorneal endotheliumen_US
dc.subjectpeptide synthesisen_US
dc.subjecttissue engineeringen_US
dc.subjectArtificial organsen_US
dc.subjectBiomimeticsen_US
dc.subjectCytologyen_US
dc.subjectFourier transform infrared spectroscopyen_US
dc.subjectPeptidesen_US
dc.subjectScaffolds (biology)en_US
dc.subjectScanning electron microscopyen_US
dc.subjectTissueen_US
dc.subjectTissue regenerationen_US
dc.subjectX ray photoelectron spectroscopyen_US
dc.subjectArtificial corneaen_US
dc.subjectBiomimetic peptidesen_US
dc.subjectCharacterizationen_US
dc.subjectCorneal endotheliumen_US
dc.subjectEndothelial-cellsen_US
dc.subjectInner surfacesen_US
dc.subjectPeptide synthesisen_US
dc.subjectSingle layeren_US
dc.subjectSurgical interventionsen_US
dc.subjectTissues engineeringsen_US
dc.subjectEndothelial cellsen_US
dc.titleBiomimetic peptide-conjugated membranes for developing an artificial corneaen_US
dc.typeConference Objecten_US

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