Biomimetic peptide-conjugated membranes for developing an artificial cornea
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Institute of Electrical and Electronics Engineers Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The corneal endothelium is composed of a single layer of specialized endothelial cells, protecting, and nourishing the inner surface of the cornea. Corneal endothelial cells do not proliferate after birth and their number decrease with age. Trauma, inflammation, or surgical intervention can cause cell loss. When damage is extensive and the density of corneal endothelial cells decreases to a critical level, it results in corneal edema and vision loss. Besides them, when corneal endothelium has irreversible damage, the only treatment way is corneal transplantation. But there are some drawbacks such as finding donors, immune reactions, and the number of patients waiting on the transplantation lists for years. Tissue engineering approaches can provide promising alternatives for the regeneration of corneal endothelium tissue. Peptides can be used to modify and functionalize the scaffolds, allowing for the production of bioactive and biomimetic surfaces. Peptide-modified scaffold surfaces might direct and enhance the behaviors of cells. In this study, the aim was to functionalize the polycaprolactone (PCL) membranes with tissue-specific peptides and to characterize the peptide-conjugated membranes by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-ray Photoelectron Spectroscopy (XPS) analysis. The synthesized peptides were successfully conjugated on the PCL biomembranes. © 2022 IEEE.
Açıklama
2022 Medical Technologies Congress, TIPTEKNO 2022 -- 31 October 2022 through 2 November 2022 -- -- 184752
Anahtar Kelimeler
characterization, corneal endothelium, peptide synthesis, tissue engineering, Artificial organs, Biomimetics, Cytology, Fourier transform infrared spectroscopy, Peptides, Scaffolds (biology), Scanning electron microscopy, Tissue, Tissue regeneration, X ray photoelectron spectroscopy, Artificial cornea, Biomimetic peptides, Characterization, Corneal endothelium, Endothelial-cells, Inner surfaces, Peptide synthesis, Single layer, Surgical interventions, Tissues engineerings, Endothelial cells
Kaynak
TIPTEKNO 2022 - Medical Technologies Congress, Proceedings
WoS Q Değeri
Scopus Q Değeri
N/A
