Ir and Turbidity Studies of Vitamin-E-Cholesterol-Phospholipid Membrane Interactions

Binary and tertiary mixture of alpha-tocophenol, cholesterol and dimyristoylphospharidylcholine in the form of multilamellar liposomes were investigated by Fourier Transform infrared and visible spectroscopy. Results of the FTIR and turbidity experiments indicate that alpha T decreases or diminishes the effect of cholesterol on the frequency and the bandwidth of the C-H stretching, CH2 scissoring and C=O stretching bands in FTIR spectra and the turbidity measurements (recorded as absorbance values at 440 nm) in phospholipid model membranes.