Correlation between intrahepatic hepatitis B virus cccDNA levels and other activity markers in patients with HBeAg-negative chronic hepatitis B infection

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dc.contributor.authorGuner, Rahmet
dc.contributor.authorKarahocagil, Mustafa
dc.contributor.authorBuyukberber, Mehmet
dc.contributor.authorKandemir, Ozlem
dc.contributor.authorUral, Onur
dc.contributor.authorUsluer, Gaye
dc.contributor.authorInan, Dilara
dc.contributor.authorKoksal, Iftihar
dc.contributor.authorBaykam, Nurcan
dc.contributor.authorHizel, Kenan
dc.contributor.authorYamazhan, Tansu
dc.contributor.authorEsen, Saban
dc.contributor.authorTasyaran, Mehmet A.
dc.date.accessioned2019-10-27T21:35:33Z
dc.date.available2019-10-27T21:35:33Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective The aim of this study was to demonstrate the relation between intrahepatic (IH) hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) levels and the other HBV replicative intermediates and hepatocyte expression of HBV antigens. Patients and methods Patients with hepatitis B surface antigen (HBsAg) positivity, hepatitis B early antigen negativity, serum HBV DNA levels 10(4) copies/ml or more, and constantly or intermittently increased alanine aminotransferase levels were included. Results Fifty-nine patients were included. There was a good correlation between the levels of IH HBV cccDNA and serum HBV DNA (P<0.001). Serum HBsAg levels were weakly correlated with IH HBV cccDNA levels and moderately correlated with serum HBV DNA (r=0.322, P=0.017; r=0.489, P=0.001, respectively). There were no significant correlation between serum HBsAg level and histologic activity index groups (P=0.691), but stage 0, 1, and greater than 2 fibrosis groups were positively correlated with serum HBsAg levels (P=0.019). IH cccDNA and serum HBV DNA were significantly different in hepatitis B core antigen staining groups (P=0.008 and <0.001, respectively) but there was no significant correlation between HBsAg staining groups and HBV replication markers. There was a weak correlation between serum HBsAg levels and IH HBsAg and hepatitis B core antigen levels (r=0.333, P=0.012; r=0.366, P=0.006, respectively). In multivariate analysis, alanine aminotransferase, age, fibrosis stage, and serum HBsAg quantitation were the most important factors predicting IH HBV cccDNA level. Conclusion Histopathologic damage, serum HBV DNA levels, and IH HBV replication markers have a more complex and dynamic process. However, both serum and IH HBV replication markers provide important knowledge about the activity of the disease. Eur J Gastroenterol Hepatol 23:1185-1191 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MEG.0b013e32834ba13aen_US
dc.identifier.endpage1191en_US
dc.identifier.issn0954-691X
dc.identifier.issue12en_US
dc.identifier.pmid21934508en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1185en_US
dc.identifier.urihttps://doi.org/10.1097/MEG.0b013e32834ba13a
dc.identifier.urihttps://hdl.handle.net/11454/45886
dc.identifier.volume23en_US
dc.identifier.wosWOS:000296752100014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatitis B core antigenen_US
dc.subjecthepatitis B early antigen-negative chronic hepatitisen_US
dc.subjecthepatitis B surface antigenen_US
dc.subjecthepatitis B virusen_US
dc.subjecthepatitis B virus covalently closed circular DNAen_US
dc.subjectimmunohistochemistryen_US
dc.subjectquantitative hepatitis B surface antigenen_US
dc.titleCorrelation between intrahepatic hepatitis B virus cccDNA levels and other activity markers in patients with HBeAg-negative chronic hepatitis B infectionen_US
dc.typeArticleen_US

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