Variables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin

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dc.contributor.authorCeylan, Bahadir
dc.contributor.authorArslan, Ferhat
dc.contributor.authorSipahi, Oguz Resat
dc.contributor.authorSunbul, Mustafa
dc.contributor.authorOrmen, Bahar
dc.contributor.authorHakyemez, Ismail N.
dc.contributor.authorTurunc, Tuba
dc.contributor.authorYildiz, Yesim
dc.contributor.authorKarsen, Hasan
dc.contributor.authorKaragoz, Gul
dc.contributor.authorTekin, Recep
dc.contributor.authorHizarci, Burcu
dc.contributor.authorTurhan, Vedat
dc.contributor.authorSenol, Sebnem
dc.contributor.authorOztoprak, Nefise
dc.contributor.authorYilmaz, Mesut
dc.contributor.authorOzdemir, Kevser
dc.contributor.authorMermer, Sinan
dc.contributor.authorKokoglu, Omer F.
dc.contributor.authorMert, Ali
dc.date.accessioned2019-10-27T11:10:40Z
dc.date.available2019-10-27T11:10:40Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. Materials and methods: This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study. The variables associated with mortality were determined by dividing the patients into groups who died or survived during hospitalisation, and who died or survived from Acinetobacter meningitis. Results: Among the 77 cases enrolled in the study, 35 were found through a literature review and 42 were cases from our centres. Forty-four cases (57.1%) were male and the median age was 48 years (range: 20-78 years). Thirty-seven patients (48%) died during hospitalisation. The variables associated with increased all-cause mortality during hospitalisation included old age (odds ratio, 1.035; 95% confidence interval (Cl), 1.004-1.067; p = 0.026) and failure to provide cerebrospinal fluid sterilisation (odds ratio, 0.264; 95% confidence interval, 0.097-0.724; p = 0.01). There is a trend (P=0.062) towards higher mortality with using of meropenem during meningitis treatment. Fifteen cases (19%) died from meningitis. There were no significant predictors of meningitis-related mortality. Conclusions: The mortality rate for central nervous system infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii is high. Old age and failure to provide CSF sterilisation are associated with increased mortality during hospitalisation. (C) 2016 Published by Elsevier B.V.en_US
dc.identifier.doi10.1016/j.clineuro.2016.12.006en_US
dc.identifier.endpage49en_US
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.pmid28013184en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2016.12.006
dc.identifier.urihttps://hdl.handle.net/11454/32418
dc.identifier.volume153en_US
dc.identifier.wosWOS:000394632300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofClinical Neurology and Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectColistinen_US
dc.subjectMeningitisen_US
dc.subjectIntratechalen_US
dc.titleVariables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistinen_US
dc.typeArticleen_US

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