Over kanserinin epidemiyolojisi ve genel sağ kalım özellikleri
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Ege Üniversitesi Hastanesinde 1992-2017 arası tanı alan ve tedavisi yapılan 1770 over kanserli olgunun epidemiyolojik ve sağ kalım özelliklerini analiz etmek ve sonuçlarını literatürle karşılaştırmaktır. Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezi tarafından toplanan over kanseri verileri CANREG özel bilgisayar programına kaydedilmiş, DSÖ ve SEER sistemleri temelinde gruplanarak analizler yapılmıştır. İstatistiksel analizlerde Ki-kare, General Linear Model, Kaplan Meier sağ kalım analizleri uygulanmıştır. Kaplan Meier sağ kalım analizinde Log Rank (Mantel-Cox), Breslow (Generalized Wilcoxon) ve Tarone-Ware istatistikleri kullanılmıştır. İstatistik analizlerde p<0,05 istatistiksel olarak anlamlı kabul edilmiştir. Bulgular: Over kanseri toplam 1770 olgu sayısıyla (%21,3) en sık görülen üçüncü jinekolojik malignitedir. Over kanserli olguların en sık görüldüğü yaş grubu 50-59 yaştır (%30,1). En sık histolojik alt tipi seröz karsinomdur (%32,3). Hastalık en sık metastatik evrede tanı almaktadır (%63,6). Beş ve 10 yılık genel sağ kalım oranı sırasıyla %56,4 ve %40,0 olarak saptanmıştır. Medyan sağ kalım süresi 76 ay olarak hesaplanmıştır. Jinekolojik kanserlerde beş ve 10 yıllık sağ kalım oranları sırasıyla %70 ve %47,2 iken; bu oran over kanseri olgularında sırasıyla %56,4 ve %40 olarak saptanmıştır. Prognoz ve sağ kalımın, endometrium ve serviks kanser olgularına göre daha kötü olduğu görülmüştür. Sonuç: Over kanseri, jinekolojik kanserler arasında önemli bir yer tutmaktadır. Hastanemizin 25 yıllık kayıtları değerlendirildiğinde, demografik verilerin ve histopatolojik bulguların literatür ile uyumlu olduğu, sağ kalım sürelerinin ise gelişmiş ülkeler ile benzer olduğu görülmektedir.
Aim: The aim of this study was to analyze the epidemiological and survival characteristics of 1770 ovarian cancer patients diagnosed and treated in Ege University Hospital between 1992 and 2017 and to compare the results with the literature. Materials and Methods: Data recorded to CANREG-4 program in EUH between 1992-2017 by EU Fight Against Cancer Research and Application Center (EUKAM) were grouped according to WHO and SEER systems. For statistical analysis, Chi-square method and general linear modeling and Kaplan-Meier analysis were performed. In Kaplan-Meier analysis, Log Rank (Mantel-Cox), Breslow (Generalized Wilcxon) and Tarone-Ware methods were used. p<0.05 was accepted as significant. Results: Ovarian cancer is the third most common gynecologic malignancy with a total of 1770 cases (21.3%). It was mostly seen at the ages between 50-59 (30.1%). The most common histologic subtype was serous carcinoma (32.3%). The disease is mostly diagnosed in the metastatic stage (63.6%). Overall survival rates of 5 and 10 years were 56.4% and 40.0%, respectively. Median survival was 76 months. The 5-year and 10-year survival rates in gynecologic cancers were 70% and 47.2%, respectively; this rate was 56.4% and 40% in ovarian cancer cases, respectively. Prognosis and survival were found to be worse than endometrial and cervical cancer. Conclusion: Ovarian cancer has an important place among gynecologic cancers due to high mortality rates. When 25 years data of our hospital was evaluated, demographic and histopathologic data were found similar with the literature, additionally survival was found similar in metastatic disease according to developed countries.
Aim: The aim of this study was to analyze the epidemiological and survival characteristics of 1770 ovarian cancer patients diagnosed and treated in Ege University Hospital between 1992 and 2017 and to compare the results with the literature. Materials and Methods: Data recorded to CANREG-4 program in EUH between 1992-2017 by EU Fight Against Cancer Research and Application Center (EUKAM) were grouped according to WHO and SEER systems. For statistical analysis, Chi-square method and general linear modeling and Kaplan-Meier analysis were performed. In Kaplan-Meier analysis, Log Rank (Mantel-Cox), Breslow (Generalized Wilcxon) and Tarone-Ware methods were used. p<0.05 was accepted as significant. Results: Ovarian cancer is the third most common gynecologic malignancy with a total of 1770 cases (21.3%). It was mostly seen at the ages between 50-59 (30.1%). The most common histologic subtype was serous carcinoma (32.3%). The disease is mostly diagnosed in the metastatic stage (63.6%). Overall survival rates of 5 and 10 years were 56.4% and 40.0%, respectively. Median survival was 76 months. The 5-year and 10-year survival rates in gynecologic cancers were 70% and 47.2%, respectively; this rate was 56.4% and 40% in ovarian cancer cases, respectively. Prognosis and survival were found to be worse than endometrial and cervical cancer. Conclusion: Ovarian cancer has an important place among gynecologic cancers due to high mortality rates. When 25 years data of our hospital was evaluated, demographic and histopathologic data were found similar with the literature, additionally survival was found similar in metastatic disease according to developed countries.
Açıklama
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Kaynak
Ege Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
58
Sayı
Supplement
