Ege Üniversitesi hastanesi veri tabanında çoklu primer kanserlerin analizi
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Ege Üniversitesi Hastanesi (EÜH) kanser veri tabanında birden çok sayıda kanserleri olan Çoklu Primer Kanser (ÇPK)’li olguların sayıca artışı dikkat çekici bulunmuş, bu artışın istatistik olarak analizi planlanmıştır. Gereç ve Yöntem: EÜH’de EÜKAM tarafından CANREG-4 özel bilgisayar programına kayıt edilen kanser verileri WHO ve Surveillance, Epidemiology, and End Results (SEER) sistemleri temelinde gruplanarak analizler yapılmıştır. İstatistik analizlerde Ki-kare, General Linear Model, Kaplan Meier sağkalım analizleri uygulanmıştır. Kaplan Meier Sağkalım analizinde Log Rank (Mantel-Cox), Breslow (Generalized Wilcoxon) ve Tarone-Ware istatistikleri kullanılmış, istatistik analizlerde p <0,05 istatistiksel olarak anlamlı kabul edilmiştir. Bulgular: EÜH veri tabanında 1992-2018 yılları arasında kaydedilmiş 124.321 kanser olgusunun 6.311’inde birden çok kanser (%5,1) saptanmıştır. ÇPK görülüşü erkeklerde daha belirgindir (p<0,0001). ÇPK’de yıllara göre bir artış saptanmıştır (p<0,0001). Her iki cinste en sık görülen Gastrointestinal sistem (GİS) kanserlerinde ÇPK genellikle yine GİS ile ilgili olmakta, bunu ürogenital sistem (ÜGS) kanserleri izlemektedir. Akciğer kanseri ile beraber görülen ÇPK’lerin başında diğer solunum sistemi kanserleri gelmekte, bunu mesane kanserleri izlemektedir. Meme kanserini izleyen ÇPK’ler endometrium ve over kanseridir. ÇPK’lerde sağkalım tek primer kanserlilere göre daha kötü ve çoklu ÇPK sayısı arttıkça sağkalımlar daha kötü olmaktadır (p<0,001). Olguların %18,2’si senkron, %81,8’i metakron olup sağkalım açısından istatistiksel olarak aradaki fark anlamlı değildir (p=0,506). Sonuç: EÜH Hastanesi veri tabanında %5,1 ÇPK saptanmış olup yıllara göre bir artış eğilimi vardır. Senkron veya metakron gelişen ÇPK’lar da sağkalım farkı bulunmamıştır. Çoklu primer kanserlerde sağkalım tekli kanserlere göre daha kötü olup ÇPK sayısı arttıkça GSK’lar daha kötü olmaktadır.
Aim: To evaluate the remarkable increase in the incidence of multiple primary cancers (MPCs) in the cancer database of Ege University Hospital (EUH). Materials and Methods: The data recorded in CANREG from EUKAM, which is special computer program, were grouped on the basis of WHO and SEER systems and analyzes were performed. In statistical analysis, chi-square, General Linear Model, and Kaplan-Meier survival curves were used. Log-Rank (Mantel-Cox), Breslow (Generalized Wilcoxon), and Tarone-Ware statistics were applied for survival analysis. p<0.05 was accepted statistically significant. Results: The total number of recorded cancer patients between 1992-2018 years was 124,321. The proportion of patients with MPCs during the searched period was 5.1% (n=6,311). MPCs were detected more common in men than in women (p<0.001). There was an increase in the incidence of MPCs over years. MPCs were most commonly detected in the gastrointestinal system (GIS) in both sexes. GIS cancers were seen as a secondary for GIS itself and GIS cancers were followed by urogenital system (UGS) cancers. MPCs seen with lung cancer were other respiratory organ cancers, as well. Bladder cancers were other commonly detected MPCs with lung cancer. Endometrium and ovary cancers were cancers which were seen as MPCs after breast cancer. Survival in MPCs was worse than in single primary cancers. Additionally, Overall survival rates were getting worse accordingly to the increase in MPCs number (p<0.001). 18.2% of the cases are synchronous, 81.7% of them are metachronous and there is no statistically significant difference in survival (p=0.506). Conclusion: In EUH cancer database, 5.1 % MPCs were detected and there was an increasing trend over the years. There is no statistically significant difference in survival of synchronous and metachronous MPCs. Survival in MPCs was worse than in single primary cancers and Overall survival rates were getting worse accordingly to the increase in MPCs number.
Aim: To evaluate the remarkable increase in the incidence of multiple primary cancers (MPCs) in the cancer database of Ege University Hospital (EUH). Materials and Methods: The data recorded in CANREG from EUKAM, which is special computer program, were grouped on the basis of WHO and SEER systems and analyzes were performed. In statistical analysis, chi-square, General Linear Model, and Kaplan-Meier survival curves were used. Log-Rank (Mantel-Cox), Breslow (Generalized Wilcoxon), and Tarone-Ware statistics were applied for survival analysis. p<0.05 was accepted statistically significant. Results: The total number of recorded cancer patients between 1992-2018 years was 124,321. The proportion of patients with MPCs during the searched period was 5.1% (n=6,311). MPCs were detected more common in men than in women (p<0.001). There was an increase in the incidence of MPCs over years. MPCs were most commonly detected in the gastrointestinal system (GIS) in both sexes. GIS cancers were seen as a secondary for GIS itself and GIS cancers were followed by urogenital system (UGS) cancers. MPCs seen with lung cancer were other respiratory organ cancers, as well. Bladder cancers were other commonly detected MPCs with lung cancer. Endometrium and ovary cancers were cancers which were seen as MPCs after breast cancer. Survival in MPCs was worse than in single primary cancers. Additionally, Overall survival rates were getting worse accordingly to the increase in MPCs number (p<0.001). 18.2% of the cases are synchronous, 81.7% of them are metachronous and there is no statistically significant difference in survival (p=0.506). Conclusion: In EUH cancer database, 5.1 % MPCs were detected and there was an increasing trend over the years. There is no statistically significant difference in survival of synchronous and metachronous MPCs. Survival in MPCs was worse than in single primary cancers and Overall survival rates were getting worse accordingly to the increase in MPCs number.
Açıklama
Anahtar Kelimeler
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Kaynak
Ege Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
59
Sayı
supplement
