The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model

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dc.contributor.authorHur, Ender
dc.contributor.authorGarip, Alev
dc.contributor.authorCamyar, Asuman
dc.contributor.authorIlgun, Sibel
dc.contributor.authorOzisik, Melih
dc.contributor.authorTuna, Sena
dc.contributor.authorOlukman, Murat
dc.contributor.authorOzdemir, Zehra Narli
dc.contributor.authorSozmen, Eser Yildirim
dc.contributor.authorSen, Sait
dc.contributor.authorAkcicek, Fehmi
dc.contributor.authorDuman, Soner
dc.date.accessioned2019-10-27T21:54:32Z
dc.date.available2019-10-27T21:54:32Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction. Acute kidney injury (AKI) pathogenesis is complex. Findings of gentamicin nephrotoxicity are seen in 30% of the AKI patients. Vitamin D has proven to be effective on renin expression, inflammatory response, oxidative stress, apoptosis, and atherosclerosis. We aimed to investigate the effect of vitamin D in an experimental rat model of gentamicin-induced AKI. Methods. Thirty nonuremic Wistar albino rats were divided into 3 groups: Control group, 1 mL saline intramuscular (im) daily; Genta group, gentamicin 100 mg/kg/day (im); Genta + vitamin D, gentamicin 100 mg/kg/day (im) in addition to 1 alpha, 25 (OH)(2)D-3 0.4 mcg/kg/day subcutaneously for 8 days. Blood pressures and 24-hour urine were measured. Blood urea and creatinine levels and urine tubular injury markers were measured. Renal histology was semiquantitatively assessed. Results. Urea, creatinine and urine neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 were all increased in Genta group indicating AKI model. Systolic blood pressure decreased, but urine volume and glutathione increased in Genta + Vit D group compared to Control group. Histological scores indicating tubular injury increased in Genta and Genta + Vit D groups. Conclusions. Vitamin D does not seem to be effective on histological findings although it has some beneficial effects via RAS system and a promising effect on antioxidant system.en_US
dc.identifier.doi10.1155/2013/313528en_US
dc.identifier.issn1687-8337
dc.identifier.issn1687-8345
dc.identifier.pmid23843788en_US
dc.identifier.urihttps://doi.org/10.1155/2013/313528
dc.identifier.urihttps://hdl.handle.net/11454/48096
dc.identifier.wosWOS:000320810800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofInternational Journal of Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Modelen_US
dc.typeArticleen_US

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