Cystic Bone Lesions: Histopathological Spectrum and Diagnostic Challenges

Basit Öğe Kaydı
dc.contributor.authorDoganavsargil, Basak
dc.contributor.authorAyhan, Ezgi
dc.contributor.authorArgin, Mehmet
dc.contributor.authorPehlivanoglu, Burcin
dc.contributor.authorKececi, Burcin
dc.contributor.authorSezak, Murat
dc.contributor.authorBasdemir, Gulcin
dc.contributor.authorOztop, Fikri
dc.date.accessioned2019-10-27T23:01:02Z
dc.date.available2019-10-27T23:01:02Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may be confused with other bone lesions. Material and Method: We retrospectively re-evaluated 143 patients diagnosed with aneurysmal bone cyst (n= 98, 68.5%), solitary bone cysts (n= 17 11.9%), pseudocyst (n= 10.7%), intraosseous ganglion (n= 3, 2.1%), hydatid cyst (n= 2; 1.4), epidermoid cyst (n= 1, 0.7%) and cysts demonstrating "mixed" aneurysmal-solitary bone cyst histology (n= 12, 8.4%), and compared them with nonparametric tests. Results: Aneurysmal bone cyst, solitary bone cysts and mixed cysts were frequently seen in the first two decades of life while the others occurred after the fourth decade. Aneurysmal bone cysts, intraosseous ganglion and pseudocysts were more common in women contrary to solitary bone cyst and mixed cysts (the female/male ratio was 1.22, 2 and 1.5 versus 0.7 and 0.5, respectively). Aneurysmal bone cyst, solitary bone cysts and "mixed" cysts were mostly seen in long bones, predominantly the femur, while epidermoid, hydatid and pseudocysts were all seen in flat bones like the vertebra, pelvis and mandible (p= 0.001, chi-square). Repeat biopsies were performed in 19 cases (13.3%), 84.2% of which were aneurysmal bone cyst (5 conventional, 9 solid, 1 secondary and 1 subperiosteal) and three (15.8%) were mixed cysts (p= 0.02, chi-square). Notably, some of them were located in inaccessible areas of pelvis (n= 3), femur (n= 3) and maxilla (n= 2). Conclusion: The most common and challenging intraosseous cysts are aneurysmal bone cysts, particularly the "solid" variant. The "mixed" aneurysmal-solitary bone cyst "subgroup" requires further research with larger series to be defined more thoroughly.en_US
dc.identifier.doi10.5146/tjpath.2014.01293en_US
dc.identifier.endpage103en_US
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue2en_US
dc.identifier.pmid25652560en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://doi.org/10.5146/tjpath.2014.01293
dc.identifier.urihttps://hdl.handle.net/11454/52099
dc.identifier.volume31en_US
dc.identifier.wosWOS:000367954000003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Zooen_US
dc.relation.ispartofTurkish Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone cystsen_US
dc.subjectAneurysmal bone cysten_US
dc.subjectSolitary bone cysten_US
dc.subjectCyst hydatiden_US
dc.subjectHistopathologyen_US
dc.titleCystic Bone Lesions: Histopathological Spectrum and Diagnostic Challengesen_US
dc.typeArticleen_US

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