Blood levels of leukotrienes (LTC4, D-4, E-4, B-4) and synthesis of leukotriene B-4 by peripheral leukocytes in children with acute A and B hepatitis

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dc.contributor.authorKasirga, E
dc.contributor.authorCoker, I
dc.contributor.authorAydogdu, S
dc.contributor.authorYagci, RV
dc.contributor.authorTaneli, B
dc.contributor.authorGousseinov, A
dc.date.accessioned2019-10-27T18:25:00Z
dc.date.available2019-10-27T18:25:00Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractLeukotrienes (LTs) are cell-membrane derived lipid inflammatory mediators, synthesized and eliminated by the liver. LTs have effects on liver cells in some pathological conditions. In this study, we measured plasma endogenous and liberated leukotriene (LT) concentration in peripheral blood leukocytes stimulated in vitro by the calcium ionophore (CaA23187) and platelet-activating factor (PAF). Production of LTs was measured in type A (n=37) and type B (n=10) acute hepatitis patients and control subjects (n=10). LTs levels were measured by high performance liquid chromatography (HPLC) and radioimmunoassay (RIA). The concentration of LTB4 measured in plasma and stimulated peripheral blood leukocyte supernatants of children with hepatitis A infection was found to be statistically elevated and in positive correlation with serum alanine aminotransferase (ALT) levels. In plasma samples of hepatitis B patients, LTC, and LTE, were measured in significantly elevated concentrations. These results suggest that LTB4 may be a critical mediator of hepatitis A virus-induced hepatocellular injury.en_US
dc.identifier.endpage465en_US
dc.identifier.issn0041-4301
dc.identifier.issue4en_US
dc.identifier.pmid10770113en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://hdl.handle.net/11454/36259
dc.identifier.volume41en_US
dc.identifier.wosWOS:000084848900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectleukotrienesen_US
dc.subjectlipid mediatorsen_US
dc.subjectacute viral hepatitisen_US
dc.titleBlood levels of leukotrienes (LTC4, D-4, E-4, B-4) and synthesis of leukotriene B-4 by peripheral leukocytes in children with acute A and B hepatitisen_US
dc.typeArticleen_US

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