Technetium-99m-DTPA aerosol scintigraphy in amiodarone induced pulmonary toxicity in comparison with Ga-67 scintigraphy

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dc.contributor.authorDirlik, A
dc.contributor.authorErinc, R
dc.contributor.authorOzcan, Z
dc.contributor.authorAtasever, A
dc.contributor.authorBacakoglu, F
dc.contributor.authorNalbantgil, S
dc.contributor.authorOzhan, M
dc.contributor.authorBurak, Z
dc.date.accessioned2019-10-27T18:42:46Z
dc.date.available2019-10-27T18:42:46Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractAmiodarone hydrochloride, which is used in life-threatening cardiac tachyarrhythmia, has been known to cause amiodarone induced pulmonary toxicity (AIPT) as a complication. In this study we aimed to investigate the clinical value of technetium-99m diethylene triamine penta-acetic acid (DTPA) aerosol lung scintigraphy in patients with AIPT in comparison with gallium-67 (Ga-67) scan. The study group included 26 cases, 7 patients with diagnosis of AIPT (Group A), 8 patients receiving amiodarone therapy but without AIPT (Group B) and I I healthy subjects as a control group (Group Q. All patients underwent Ga-67 and Tc-99m-DTPA aerosol scintigraphy in addition to various laboratory tests, Ga-67 scintigraphy was positive in 4 of 7 AIPT patients but quite normal in Group B. A positive correlation was found (r = 0.52, p < 0.05) between kep values determined by Tc-99m-DTPA aerosol scintigraphy and the cumulative dose of amiodarone. The mean kep values were 2.04% +/- 0.85%/min, 1.30% +/- 0.42%/min and 0.86% +/- 0.19%/min for groups A, B and C, respectively. ne mean clearance rate of group A was significantly faster than that of normals (p < 0.0005) and group B (p = 0.028). In addition, there was a significant difference between groups B and C (p = 0.015). In conclusion, Ga-67 lung scintigraphy is a useful method for the detection of AIPT but Tc-99m-DTPA aerosol scintigraphy offers better results than Ga-67 scintigraphy. Early changes in Tc-99m-DTPA clearance may be observed in patients receiving amiodarone. The kep value in patients with AIPT is noticeably increased with respect to the control group. With its favorable physical properties, low cost, lower radiation burden and its ability to be used as an objective measure for the pulmonary clearance rate, Tc-99m-DTPA aerosol scintigraphy appears to be promising in patients receiving amiodarone therapy.en_US
dc.identifier.doi10.1007/BF02988644en_US
dc.identifier.endpage481en_US
dc.identifier.issn0914-7187
dc.identifier.issue7en_US
dc.identifier.pmid12508838en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage477en_US
dc.identifier.urihttps://doi.org/10.1007/BF02988644
dc.identifier.urihttps://hdl.handle.net/11454/37153
dc.identifier.volume16en_US
dc.identifier.wosWOS:000179724100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapanese Society Nuclear Medicineen_US
dc.relation.ispartofAnnals of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamiodaroneen_US
dc.subjectGa-67 scintigraphyen_US
dc.subjectTc-99m-DTPA radioaerosol scintigraphyen_US
dc.titleTechnetium-99m-DTPA aerosol scintigraphy in amiodarone induced pulmonary toxicity in comparison with Ga-67 scintigraphyen_US
dc.typeArticleen_US

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