Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis

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dc.contributor.authorBuduneli, Nurcan
dc.contributor.authorKinane, Denis F.
dc.date.accessioned2019-10-27T21:24:56Z
dc.date.available2019-10-27T21:24:56Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractP>Background A major challenge in clinical periodontics is to find a reliable molecular marker of periodontal tissue destruction with high sensitivity, specificity and utility. Objectives The aim of this systematic review is to evaluate available literature on 'the utility of molecular markers of soft and hard periodontal tissue destruction'. Materials and Methods Based on the focused question, 'What is the utility of molecular markers of soft and hard periodontal tissue destruction', an electronic and manual search was conducted for human studies presenting clinical data for the potential of molecular markers of tissue destruction in biofluids; gingival crevicular fluid (GCF), saliva, and serum. Results Papers fulfilling the inclusion criteria were selected. All relevant data from the selected papers were extracted and recorded in separate tables for molecules in GCF, saliva, and serum. Conclusion Within the defined limits of the Problem/Population, Intervention, Comparison, Outcome, the present analysis reveals that (a) no single or combination of markers exists that can disclose periodontal tissue destruction adequately; (b) while the most fruitful source of biomarkers for periodontal destruction appears to be in molecules tightly related to bone and soft tissue destruction, this remains to be objectively demonstrated. Currently, clinical measurements are still the most reliable.en_US
dc.description.sponsorshipEge UniversityEge University; United States Public Health Service National Institute of Health, NIDCRUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Dental & Craniofacial Research (NIDCR) [DE017384]; Colgateen_US
dc.description.sponsorshipThis work was supported in part by Ege University (NB) and by the United States Public Health Service National Institute of Health, NIDCR Grant DE017384 to D. F. K. This supplement was supported by an unrestricted grant from Colgate.en_US
dc.identifier.doi10.1111/j.1600-051X.2010.01670.xen_US
dc.identifier.endpage105en_US
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.pmid21323706en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-051X.2010.01670.x
dc.identifier.urihttps://hdl.handle.net/11454/44704
dc.identifier.volume38en_US
dc.identifier.wosWOS:000287402800010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiomarkersen_US
dc.subjectdiagnosisen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectperiodontal diseaseen_US
dc.subjectsalivaen_US
dc.subjectserumen_US
dc.titleHost-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitisen_US
dc.typeReview Articleen_US

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