A concentration dependent spectroscopic study of binary mixtures of plant sterol stigmasterol and zwitterionic dimyristoyl phosphatidylcholine multilamellar vesicles: An FTIR study

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dc.contributor.authorUnsalan, Cisem Altunayar
dc.contributor.authorSahin, Ipek
dc.contributor.authorKazanci, Nadide
dc.date.accessioned2019-10-27T09:59:30Z
dc.date.available2019-10-27T09:59:30Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description3rd International Turkish Congress on Molecular Spectroscopy (TURCMOS) -- AUG 26-29, 2017 -- Bodrum, TURKEYen_US
dc.description.abstractPlant sterols such as stigmasterol and sitosterol are mostly found in plant cell walls and membranes and have been used as cholesterol-lowering agents as well as anti-inflammatory, antibacterial, antifungal, anti-ulcerative and antitumor activities. This study was conducted to examine the thermotropic and physicochemical properties of binary mixtures of plant sterol stigmasterol and zwitterionic dimyristoyl phosphatidylcholine (DMPC) multilamellar vesicles (MLVs) as a function of temperature and different stigmasterol concentrations by utilizing Fourier transform infrared (FTIR) spectroscopy. In this study, we observed that stigmasterol incorporation induces variations in the lipid thermotropic phase behavior, lipid order (acyl chain flexibility) and dynamics (fluidity) and hydration state of the head group and/or the region near the head group of DMPC MLVs. Our results suggest that stigmasterol is fully capable of interacting with zwitterionic DMPC membranes and changes the biophysical properties of them. (C) 2018 Published by Elsevier B.V.en_US
dc.description.sponsorshipEge University Research FundEge University [2013 FEN 033]en_US
dc.description.sponsorshipThis work was supported by Ege University Research Fund 2013 FEN 033.en_US
dc.identifier.doi10.1016/j.molstruc.2018.02.100
dc.identifier.endpage132en_US
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.issn0022-2860en_US
dc.identifier.issn1872-8014en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2018.02.100
dc.identifier.urihttps://hdl.handle.net/11454/29632
dc.identifier.volume1174en_US
dc.identifier.wosWOS:000449132500020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStigmasterolen_US
dc.subjectDimyristoyl phosphatidylcholineen_US
dc.subjectMembraneen_US
dc.subjectFourier transform infrared spectroscopyen_US
dc.titleA concentration dependent spectroscopic study of binary mixtures of plant sterol stigmasterol and zwitterionic dimyristoyl phosphatidylcholine multilamellar vesicles: An FTIR studyen_US
dc.typeArticleen_US

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