A concentration dependent spectroscopic study of binary mixtures of plant sterol stigmasterol and zwitterionic dimyristoyl phosphatidylcholine multilamellar vesicles: An FTIR study
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Plant sterols such as stigmasterol and sitosterol are mostly found in plant cell walls and membranes and have been used as cholesterol-lowering agents as well as anti-inflammatory, antibacterial, antifungal, anti-ulcerative and antitumor activities. This study was conducted to examine the thermotropic and physicochemical properties of binary mixtures of plant sterol stigmasterol and zwitterionic dimyristoyl phosphatidylcholine (DMPC) multilamellar vesicles (MLVs) as a function of temperature and different stigmasterol concentrations by utilizing Fourier transform infrared (FTIR) spectroscopy. In this study, we observed that stigmasterol incorporation induces variations in the lipid thermotropic phase behavior, lipid order (acyl chain flexibility) and dynamics (fluidity) and hydration state of the head group and/or the region near the head group of DMPC MLVs. Our results suggest that stigmasterol is fully capable of interacting with zwitterionic DMPC membranes and changes the biophysical properties of them. (C) 2018 Published by Elsevier B.V.
Açıklama
3rd International Turkish Congress on Molecular Spectroscopy (TURCMOS) -- AUG 26-29, 2017 -- Bodrum, TURKEY
Anahtar Kelimeler
Stigmasterol, Dimyristoyl phosphatidylcholine, Membrane, Fourier transform infrared spectroscopy
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
1174
