Melatonin Attenuates Histopathological Changes in the Hippocampus of Infantile Rats with Kaolin-Induced Hydrocephalus

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dc.contributor.authorTurgut, Mehmet
dc.contributor.authorBaka, Meral
dc.contributor.authorUyanikgil, Yigit
dc.date.accessioned2019-10-27T10:45:44Z
dc.date.available2019-10-27T10:45:44Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective/Aim: Hydrocephalus is defined as an incapacitating neurological disorder characterized by ventricular enlargement in children, but the effects of melatonin on this hydrocephalus have not yet been fully elucidated. In the present experiment, we attempted to investigate the effects of exogenous melatonin administration on hydrocephalus-induced hippocampal changes in infantile rats. Methods: In this study, we randomly divided 45 Swiss albino rats aged 2 weeks into 3 groups: group I, the control group received a sham injection with needle insertion only; groups II and III were given kaolin injections before treatment - group II, the hydrocephalus group, was treated with an isotonic NaCl solution, and group III, the hydrocephalus plus melatonin group, was treated with 0.5 mg/100 g body weight of exogenous melatonin. Both immunohistochemical and histological analyses were performed after hydrocephalus induction and melatonin administration. Immunohistochemical staining consisted antiglial fibrillary acidic protein staining. The TUNEL technique was used for defining quantitate apoptosis. Results: Melatonin administration significantly attenuated chronic hydrocephalus-induced histopathological changes in the hippocampal subregions of infantile rats. Compared to hydrocephalic rats treated with saline solution, melatonin significantly decreased the number of apoptotic cells and pyknotic index values of each hippocampal subregion after the kaolin-induced hydrocephalus (p < 0.001). Conclusion: The present results demonstrate that the chronic hydrocephalus-induced histopathological changes in the hippocampus were partially reversible with melatonin treatment, suggesting its neuroprotective effects in infantile rats. However, these findings need to be confirmed by further experimental studies and clinical trials. (C) 2018 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000488497en_US
dc.identifier.endpage237en_US
dc.identifier.issn1016-2291
dc.identifier.issn1423-0305
dc.identifier.issue4en_US
dc.identifier.pmid29791910en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage229en_US
dc.identifier.urihttps://doi.org/10.1159/000488497
dc.identifier.urihttps://hdl.handle.net/11454/31196
dc.identifier.volume53en_US
dc.identifier.wosWOS:000435963700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofPediatric Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHippocampusen_US
dc.subjectHydrocephalusen_US
dc.subjectKaolinen_US
dc.subjectMelatoninen_US
dc.subjectPyknotic indexen_US
dc.titleMelatonin Attenuates Histopathological Changes in the Hippocampus of Infantile Rats with Kaolin-Induced Hydrocephalusen_US
dc.typeArticleen_US

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