Effects of octreotide and propranolol on colonic mucosa in rats with portal hypertensive colopathy

Basit Öğe Kaydı
dc.contributor.authorAydede, H
dc.contributor.authorSakarya, A
dc.contributor.authorErhan, Y
dc.contributor.authorKara, E
dc.contributor.authorIlkgul, O
dc.contributor.authorOzdemir, N
dc.date.accessioned2019-10-27T18:59:29Z
dc.date.available2019-10-27T18:59:29Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/Aims: The aim of the study is to clarify the effects of actreotide and propranolol, agents used in the treatment of portal hypertension, on mucosal changes in portal hypertensive colopathy. Methodology: Portal hypertension was induced in all rats by partial portal vein ligation, and after the operation all rats were caged for a 10-week period. Then, animals were divided into three groups and for two weeks medical treatment were administered to the individual groups as follows: Control group, octreotide 100 mup/kg/12 hours, subcutaneously. Propranolol group, propranolol 20 mg/kg/day, intraperitoneally. In order to assess the portal hypertensive colopathy, criteria such as mean diameters of dilated vessels in colonic mucosa, and the existence of mucosal edema, capillary ectasia, hyperemia and hemorrhage inflammation were used. Results: When parameters were compared for the control versus propranolol groups, mucosal edema and hyperemia and hemorrhage criteria were found to be significant for the propranolol group; control versus octreotide groups, mucosal edema, capillary ectasia, and hyperemia and hemorrhage criteria were found to be significant for the octreotide group; octreotide versus propranolol groups, capillary ectasia and mucosal edema criteria were found to be significant for the octreotide group. Conclusions: The mucosal changes in portal hypertensive colopathy could be corrected by drugs modifying portal blood flow, octreotide may find a place in the treatment of portal hypertensive colopathy.en_US
dc.identifier.endpage1355en_US
dc.identifier.issn0172-6390
dc.identifier.issue53en_US
dc.identifier.pmid14571736en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1352en_US
dc.identifier.urihttps://hdl.handle.net/11454/37637
dc.identifier.volume50en_US
dc.identifier.wosWOS:000185549200040en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectportal hypertensionen_US
dc.subjectcolonen_US
dc.subjectoctreotideen_US
dc.subjectpropranololen_US
dc.subjectratsen_US
dc.titleEffects of octreotide and propranolol on colonic mucosa in rats with portal hypertensive colopathyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu